Atherosclerosis is initiated when the lipids part of LDL accumulate and oxidize inside the arteries. Lipid retention and oxidation triggers recruitment and activation of leukocytes, establishing the chronic inflammation characteristic of atherosclerosis [1]. Recent data suggest a new role for an old player, a signaling receptor recognizing minimally modified LDL (mmLDL), and also introduces a new cellular player in atherosclerosis, the Thl7 cell.
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