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首页> 外文期刊>Current opinion in lipidology >Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.
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Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.

机译:肾特异性摄取类固醇激素25-羟基维生素D3的途径。

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摘要

Steroid hormones are believed to enter cells solely by free diffusion through the plasma membrane. However, recent work on the uptake of 25-hydroxyvitamin D3 into the kidney has identified an endocytic pathway that is responsible for the delivery of this steroid to renal tissues. This finding led to a new perception that endocytosis may play an important role in the cell-type-specific targeting and uptake of steroid hormones. In the present review, we describe the molecular components (e.g. steroid carriers, endocytic receptors and intracellular transport proteins) that constitute this novel pathway for tissue-specific uptake of vitamin D metabolites.
机译:据信类固醇激素仅通过质膜自由扩散进入细胞。但是,最近有关将25-羟基维生素D3摄入肾脏的工作已经确定了一种内吞途径,该途径负责将类固醇递送至肾脏组织。这一发现引起了新的认识,即内吞作用可能在类固醇激素的细胞类型特异性靶向和摄取中起重要作用。在本综述中,我们描述了构成这种维生素D代谢物组织特异性吸收新途径的分子成分(例如类固醇载体,内吞受体和细胞内转运蛋白)。

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