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The effect of timing of influenza vaccination and sample collection on antibody titers and responses in the aged

机译：流感疫苗接种和样品收集对老年抗体滴度和反应的影响

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Antibody responses, B cell subset distribution in blood and the blood transcriptome were analyzed in younger and aged human subjects before and after vaccination with the inactivated influenza vaccine. In the aged, but not the younger, individuals we saw a clear difference in antibody titers including those at baseline depending on the time of vaccination and sample collection. Differences in baseline titers in aged individuals treated in the morning or afternoon in turn affected responsiveness to the vaccine. In both younger and aged individuals, the time of sample collection also affected relative numbers of some of the B cell subsets in blood. A global gene expression analysis with whole blood samples from the aged showed small but statistically significant differences depending on the time of sample collection. Our data do not indicate that timing of vaccination affects immune responsiveness of the aged, but rather shows that in clinical influenza vaccine trials timing of collection of samples can have a major and potentially misleading influence on study outcome. In future vaccine trials, timing of vaccination and sample collection should be recorded carefully to allow for its use as a study covariant. (C) 2017 Elsevier Ltd. All rights reserved.
机译：用灭活的流感疫苗接种前后分析血液和血液转录组中的抗体反应，B细胞血液转录组分布。在老年人，但不是年轻人，个人我们看到抗体滴度的明显差异，包括基线的抗体滴度，这取决于疫苗接种的时间和样品收集。在早晨或下午治疗的老年人的基线滴度的差异反过来影响对疫苗的反应。在较年轻和年龄的个体中，样品收集的时间也影响了血液中一些B细胞亚群的相对数量。根据样品收集时间，来自年龄的全血样品的全血样品的全球基因表达分析表现出小但统计学上显着的差异。我们的数据表明，疫苗接种的时序会影响老年人的免疫反应性，而是表现出在临床流感疫苗试验中，样品收集的时序可以对研究结果产生重大和潜在的误导性影响。在未来的疫苗试验中，应仔细记录疫苗接种和样品收集时的时间，以便允许其作为研究协会的使用。 （c）2017 Elsevier Ltd.保留所有权利。

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