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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Ru(II)/diclofenac-based complexes: DNA, BSA interaction and their anticancer evaluation against lung and breast tumor cells
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Ru(II)/diclofenac-based complexes: DNA, BSA interaction and their anticancer evaluation against lung and breast tumor cells

机译：Ru（II）/双氯芬酸的复合物：DNA，BSA相互作用及其对肺和乳腺肿瘤细胞的抗癌评估

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摘要

Ruthenium(II) diclofenac-based complexes of the general formula (Ru(dicl)(P-P)(bpy)]PF6 (did = diclofenac, bpy = 2,2'-bipyridine, and P-P = 1,4'-bis(diphenylphosphino)butane (dppb) (1), 1,2'-bis(diphenylphosphino)ethane (dppe) (2), 1,3'-bis(diphenylphosphino)propane (dppp) (3) and 1,1'-bis(diphenylphosphino) ferrocene (dppf) (4)1 are synthesized. The complexes (1-4) are characterized by elemental analyses, infrared, NMR, and UV-vis spectroscopy and (3) and (4) are characterized by single crystal X-ray diffraction. The DNA binding of complexes (1-4), studied by circular dichroism (CD) and Hoechst 33 258 staining assay, indicates their binding with the minor grooves. The complexes interact with BSA with binding constants (K-b) in the range of 2.5 x 10(3) -5.5 x 10(4) M-1. The complexes exhibit high cytotoxicity against the tumor cell lines A549, MDA-MB-231, and MCF-7 with IC50 values ranging from 0.56 to 15.28 mu M. The complexes are more selective for the hormone-dependent MCF-7 breast tumor cell line and complex (1) is the most potent one. The study demonstrates the anticancer activity of ruthenium(ii)/diclofenac-based complexes.
机译：钌（II）通式（Ru（DIC1）（PP）（PP）（PP）（BPY）] PF6（DIClofenac，BPy = 2,2'-Bi0赖丁，和PP = 1,4'-BIS（二苯基膦基）丁烷（DPPB）（1），1,2'-BIS（二苯基膦基）乙烷（DPPE）（2），1,3'-双（二苯基膦基）丙烷（DPPP）（3）和1,1'-BIS（合成二苯基膦酰基膦酰基膦酰基膦氨基硫基）二茂铁（DPPF）（4）1。复合物（1-4）的特征在于元素分析，红外，NMR和UV-Vis光谱和（3）和（4）的特征在于单晶X-射线衍射。通过圆形二色性（CD）和Hoechst 33 258染色测定研究的络合物（1-4）的DNA结合表明它们与次要凹槽的结合。复合物与BSA相互作用，在该范围内具有结合常数（KB） 2.5×10（3）-5.5 x 10（4）m-1。复合物对肿瘤细胞系A549，MDA-231和MCF-7具有高细胞毒性，IC50值范围为0.56至15.28 mu m 。复合物对激素依赖性MCF-7乳房更具选择性肿瘤细胞系和复合物（1）是最有效的。该研究证明了钌（II）/双氯芬酸基复合物的抗癌活性。

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