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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Nucleophilic substitution: a facile strategy for selective B-H functionalization of carboranes
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Nucleophilic substitution: a facile strategy for selective B-H functionalization of carboranes

机译：亲核替代：碳钢植物选择性B-H官能化的容易策略

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Vertex-specific functionalization of carboranes has received considerable research interest, due to the valuable application of carborane derivatives in medicine, coordination/organometallic chemistry and materials. In comparison with a protic cage C-H bond, cage B-H is hydridic and generally less polar, with a bond dissociation energy of ca. 108 kcal mol(-1). These features make B-H activation quite different from that of the C-H bond. In addition, selectivity among ten very similar BH vertices in o-carborane is challenging yet crucial to the effective construction of carborane-based functional molecules. To address these issues, a brand new strategy of cage B-H nucleophilic substitution has recently been presented and developed for straightforward and regioselective cage B-H functionalization. The regioselectivity can be controlled by the electronic/steric properties of the cage carbon substituents. This Frontier article highlights the recent advancement in the nucleophilic cage B-H substitution of carboranes.
机译：由于碳硼烷衍生物在医学，协调/有机金属化学和材料中的宝贵应用，Carboranes的顶点特异性官能化受到了相当大的研究兴趣。在与质子笼C-H键相比，保持架B-H是氢负离子，并且通常较少极性，用约的键离解能108 kcal mol（-1）。这些特征使B-H激活与C-H键的相似。此外，O-Carborane中十个非常相似的BH顶点之间的选择性是挑战，对于基于碳硼烷的功能分子的有效构建至关重要。为了解决这些问题，最近已经提出了一种全新的笼式B-H亲核替代策略，并为直接和区域选择性笼式的B-H官能化开发。可以通过笼碳取代基的电子/空间性能来控制区域选择性。这个边界文章突出了碳钢烷基核酸笼式B-H替代的最新进步。

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