...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diabetes care >Cardiovascular characteristics in subjects with increasing levels of abnormal glucose regulation: The strong heart study
【24h】

Cardiovascular characteristics in subjects with increasing levels of abnormal glucose regulation: The strong heart study

机译：葡萄糖调控水平增加的受试者心血管特征：强烈的心脏研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE-To evaluate whether impaired fasting glucose (IFG) or the combination of IFG and impaired glucose tolerance (IGT) is associated with progressive abnormalities of cardiac geometry and function. RESEARCH DESIGN AND METHODS-We studied 562 nondiabetic (311 women), nonhypertensive participants of the second Strong Heart Study exam, without prevalent cardiovascular (CV) disease and with estimated glomerular filtration rate ??60 mL/min/1.73 m 2 (age 46-65 years, 198 with isolated IFG [35%], and 132 with combined IFG and IGT [23%]). Anthropometric parameters, insulin resistance, fibrinogen, C-reactive protein (CRP), lipid profile, blood pressure (BP), and echocardiographic parameters were compared with 232 participants with normal glucose tolerance (NGT). RESULTS-BMI, prevalence of central obesity, homeostaticmodel assessment index of insulin resistance, plasma triglycerides, fibrinogen, and CRP increased progressively across categories of glucose intolerance (P 0.0001), with the IFG+IGT group having higher values than those with isolated IFG (0.05P0.0001). Compared withNGT, both IFG and IFG+IGT exhibited greater left ventricular (LV) mass (P 0.0001) and lower Doppler early peak rapid filling velocity to peak atrial filling velocity ratio (P 0.005), without differences in LV systolic function. The odds of LV hypertrophy (LV mass index 46.7 in women or 49.2 g/m2.7 in men) was 3.5 in IFG participants (95% CI 0.68-17.76; P = NS) and 9.76 (2.03-46.79; P = 0.004) in IFG+IGT, compared with NGT, after adjustment for age, sex, heart rate, systolic BP, and waist circumference (WC). In the overall sample, LV mass index was associated with WC (P = 0.033), CRP (P = 0.027), and 2-h oral glucose tolerance test (P = 0.001) independently of confounders. CONCLUSIONS-Cardiometabolic profile and markers of inflammation are more severely altered in men and women with both IFG and IGT compared with those with IFG alone. These individuals, in the absence of hypertension, have a 10-fold greater probability of preclinical CV disease (LV hypertrophy). ? 2013 by the American Diabetes Association.
机译：目的 - 评估是否有禁止的空腹葡萄糖（IFG）或IFG和受损葡萄糖耐量（IGT）的组合与心脏几何形状和功能的逐渐异常相关。研究设计与方法 - 我们研究了562名非奶昔（311名女性），第二次强心病学习考试的非专利参与者，没有普遍存在的心血管（CV）疾病，估计肾小球过滤速率为60 ml / min / 1.73 m 2（46岁-65岁，198年，孤立的ifg [35％]，132次，具有组合IFG和IGT [23％]）。将胰岛素抵抗，纤维蛋白原，C反应蛋白（CRP），脂质曲线，血压（BP）和超声心动图参数与正常葡萄糖耐量（NGT）进行比较。结果-BMI，中央肥胖的患病率，胰岛素抵抗，血浆甘油三酯，纤维蛋白原和CRP的稳态性表达评估指标跨越葡萄糖不耐受（P <0.0001），具有比具有较高值的​​IFG + IGT组的分类增加IFG（0.05＆ 0.0001）。与IFG和IFG + IGT两者均显示出较大的左心室（LV）质量（P <0.0001），较低的多普勒早期峰值快速填充速度，以峰心房填充速度比（P <0.005），没有LV收缩功能的差异。 IFG参与者的LV肥大（LV质量指数＆ 46.7）的几率（LV大规模指数＆ 46.7）在IFG参与者中为3.5（95％CI 0.68-17.76; p = ns）和9.76（2.03-46.79; P = 0.004）在IFG + IGT中，与NGT相比，调整年龄，性别，心率，收缩压BP和腰围（WC）。在整个样品中，LV质量指数与WC（P = 0.033），CRP（P = 0.027）和2-H口腔葡萄糖耐量试验（P = 0.001）与混凝剂无关。结论 - 使用IFG和IGT的男性和女性更严重改变炎症的心肌曲线和炎症的标记与IFG单独的人相比。在没有高血压的情况下，这些个体具有10倍的临床前CV疾病（LV肥大）的概率。还是2013年由美国糖尿病协会。

著录项

  • 来源
    《Diabetes care》 |2013年第4期|共6页
  • 作者

    CapaldoB.; DiBonitoP.; IaccarinoM.; RomanM.J.; LeeE.T.; DevereuxR.B.; RiccardiG.; HowardB.V.; DeSimoneG.;

  • 作者单位

    Department of Clinical and Experimental Medicine Federico II University Naples Italy;

    Department of Internal Medicine Pozzuoli Hospital Naples Italy;

    Department of Clinical and Experimental Medicine Federico II University Naples Italy;

    Department of Medicine Weill Cornell Medical College New York NY United States;

    Center for American Indian Health Research University of Oklahoma Oklahoma City OK United States;

    Department of Medicine Weill Cornell Medical College New York NY United States;

    Department of Clinical and Experimental Medicine Federico II University Naples Italy;

    Medstar Health Research Institute Washington DC United States;

    Department of Clinical and Experimental Medicine Federico II University Naples Italy Department;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号