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首页> 外文期刊>Diabetes care >Should Viscous Fiber Supplements Be Considered in Diabetes Control? Results From a Systematic Review and Meta-analysis of Randomized Controlled Trials
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Should Viscous Fiber Supplements Be Considered in Diabetes Control? Results From a Systematic Review and Meta-analysis of Randomized Controlled Trials

机译：是否应该在糖尿病控制中考虑粘性纤维补充剂？ 系统评价和随机对照试验的荟萃分析

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摘要

OBJECTIVE Evidence from randomized controlled trials (RCTs) suggests that viscous dietary fiber may offer beneficial effects on glycemic control and, thus, an improved cardiovascular disease risk profile. Our purpose was to conduct a systematic review and meta-analysis of RCTs to synthesize the therapeutic effect of viscous fiber supplementation on glycemic control in type 2 diabetes. RESEARCH DESIGN AND METHODS MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were searched through 15 June 2018. We included RCTs >= 3 weeks in duration that assessed the effects of viscous fiber on markers of glycemic control in type 2 diabetes. Two independent reviewers extracted data. Data were pooled using the generic inverse variance method and expressed as mean differences (MD) with 95% CIs. Heterogeneity was assessed (Cochran Q statistic) and quantified (I-2 statistic). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the overall certainty of the evidence. RESULTS We identified 28 eligible trial comparisons (n = 1,394). Viscous fiber at a median dose of similar to 13.1 g/day significantly reduced HbA(1c) (MD -0.58% [95% CI -0.88, -0.28]; P = 0.0002), fasting blood glucose (MD -0.82 mmol/L [95% CI -1.32, -0.31]; P = 0.001), and HOMA-insulin resistance (IR) (MD -1.89 [95% CI -3.45, -0.33]; P = 0.02) compared with control and in addition to standard of care. The certainty of evidence was graded moderate for HbA(1c), fasting glucose, fasting insulin, and HOMA-IR and low for fructosamine. CONCLUSIONS Viscous fiber supplements improve conventional markers of glycemic control beyond usual care and should be considered in the management of type 2 diabetes.
机译：来自随机对照试验（RCT）的客观证据表明，粘性膳食纤维可能对血糖控制的有益作用以及改善的心血管疾病风险概况。我们的目的是对RCT进行系统审查和荟萃分析，以综合粘性纤维补充对2型糖尿病血糖对照的治疗效果。研究设计和方法Medline，Embase和Cochrane中央登记的受控试验中央登记术于2018年6月15日。我们包括RCT> = 3周的持续时间，评估粘性纤维对2型糖尿病患者血糖控制标志物的影响。两个独立审阅者提取数据。使用通用逆变异方法汇集数据，并表示为具有95％CIS的平均差异（MD）。评估异质性（Cochran Q统计学）和量化（I-2统计）。建议评估，发展和评估（等级）方法的评分用于评估证据的整体确定性。结果我们确定了28个符合条件的试验比较（n = 1,394）。类似于13.1g /天的中值剂量的粘性纤维显着降低HBA（1c）（MD -0.58％[95％CI -0.88,0.28]; p = 0.0002），空腹血糖（MD -0.82 mmol / L. [95％CI -1.32，-0.31]; p = 0.001），与对照相比，HOMA-胰岛素抵抗（IR）（MD -1.89 [95％CI -3.45，-0.33]; P = 0.02）护理标准。证据的确定性为HBA（1C），空腹葡萄糖，空腹胰岛素和HOMA-IR和低适用于果糖胺的次数。结论粘性纤维补充剂改善血糖控制的常规标志物超越通常护理，应在2型糖尿病的管理中考虑。

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  • 来源
    《Diabetes care》 |2019年第5期|共12页
  • 作者

    Jovanovski Elena; Khayyat Rana; Zurbau Andreea; Komishon Allison; Mazhar Nourah; Sievenpiper John L.; Mejia Sonia Blanco; Hoang Vi Thanh Ho; Li Dandan; Jenkins Alexandra L.; Duvnjak Lea; Vuksan Vladimir;

  • 作者单位

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

    Univ Zagreb Vuk Vrhovac Univ Clin Diabet Endocrinol &

    Metab D Merkur Univ Hosp Sch Med Zagreb;

    St Michaels Hosp Clin Nutr &

    Risk Factor Modificat Ctr Toronto ON Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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