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首页> 外文期刊>Diabetes care >The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials
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The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

机译：液体膳食替代对2型糖尿病患者超重/肥胖个体心脏造成危险因素的影响：随机对照试验的系统回顾和荟萃分析

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摘要

OBJECTIVE The evidence for liquid meal replacements in diabetes has not been summarized. Our objective was to synthesize the evidence of the effect of liquid meal replacements on cardiometabolic risk factors in overweight/obese individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS Data sources included MEDLINE, EMBASE, and the Cochrane Library through 10 December 2018. We included randomized trials of >= 2 weeks assessing the effect of liquid meal replacements in weight loss diets compared with traditional weight loss diets on cardiometabolic risk factors in overweight/obese subjects with type 2 diabetes. Two independent reviewers extracted relevant data and assessed risk of bias. Data were pooled using the inverse variance method. The overall certainty of the evidence was evaluated using GRADE (Grading of Recommendations Assessment, Development and Evaluation). RESULTS Nine trial comparisons (N = 961 [median follow-up 24 weeks]) met eligibility criteria. Mean differences were for body weight -2.37 kg (95% CI -3.30 to -1.44), BMI -0.87 kg/m(2) (-1.31 to -0.42), body fat -1.66% (-2.17 to -1.15), waist circumference -2.24 cm (-3.72 to -0.77), HbA(1c) -0.43% (-0.66 to -0.19) (-4.7 mmol/mol [-7.2 to -2.1]), fasting glucose -0.63 mmol/L (-0.99 to -0.27), fasting insulin -11.83 pmol/L (-23.11 to -0.54), systolic blood pressure -4.97mmHg (-7.32 to -2.62), and diastolic blood pressure -1.98 mmHg (-3.05 to -0.91). There was no effect on blood lipids. The overall certainty of the evidence was low to moderate owing to imprecision and/or inconsistency. CONCLUSIONS Liquid meal replacements in weight loss diets lead to modest reductions in body weight, BMI, and systolic blood pressure, and reductions of marginal clinical significance in body fat, waist circumference, HbA(1c), fasting glucose, fasting insulin, and diastolic blood pressure. More high-quality trials are needed to improve the certainty in our estimates.
机译：目的尚未总结糖尿病液膳食替代品的证据。我们的目标是综合液体膳食替代对2型糖尿病患者超重/肥胖个体的心脏造成危险因素的效果的证据。研究设计和方法数据来源包括2018年12月10日的Medline，Embase和Cochrane图书馆。我们包括随机试验> = 2周的试验，评估减肥饮食中液体膳食替代品的效果与心脏异构危险因素的传统体重减轻饮食相比在超重/肥胖患有2型糖尿病的受试者中。两个独立审稿人提取了相关数据并评估了偏见的风险。使用逆方差方法汇集数据。使用成绩评估证据的整体确定性（建议评估，开发和评估等级）。结果九次试验比较（n = 961 [24周中间24周]）达到了资格标准。体重的平均差异-2.37kg（95％CI -3.30至-1.44），BMI -0.87 kg / m（2）（-1.31至-0.42），体脂肪-1.66％（-2.17至-1.15），腰围-2.24厘米（-3.72至-0.77），HBA（1c）-0.43％（-0.66至-0.19）（-4.7mmol / mol [-7.2至-2.1]），禁食葡萄糖-0.63 mmol / l（ -0.99至-0.27），禁食胰岛素-11.83 pmol / l（-23.11至-0.54），收缩压-4.97mmHg（-7.32至-2.62），舒张血压-1.98 mmHg（-3.05至-0.91） 。对血脂没有影响。由于不精确和/或不一致，证据的整体确定性低于中等。结论减肥饮食中的液体膳食更换导致体重，BMI和收缩压的适度降低，以及减少体脂，腰围，HBA（1C），空腹，空腹胰岛素和舒张血液中边际临床意义的边际临床意义压力。需要更高质量的试验来提高我们估计的确定性。

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  • 来源
    《Diabetes care》 |2019年第5期|共10页
  • 作者

    Noronha Jarvis C.; Nishi Stephanie K.; Braunstein Catherine R.; Khan Tauseef A.; Mejia Sonia Blanco; Kendall Cyril W. C.; Kahleova Hana; Rahelic Dario; Salas-Salvado Jordi; Leiter Lawrence A.; Sievenpiper John L.;

  • 作者单位

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    Inst Clin &

    Expt Med Diabet Ctr Prague Czech Republic;

    Dubrava Univ Hosp Dept Endocrinol Diabet &

    Clin Pharmacol Zagreb Croatia;

    Inst Salud Carlos III CIBER Fisiopatol Obesidad &

    Nutr CIBERObn Madrid Spain;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

    St Michaels Hosp Toronto 3D Diet Digest Tract &

    Dis Knowledge Synt Clin Nutr &

    Risk Factor;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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