Extracellular vs Intracellular Delivery of CO: Does It Matter for a Stable, Diffusible Gasotransmitter?

Soboleva Tatiana; Simons Casey R.; Arcidiacono Ashley; Benninghoff Abby D.; Berreau Lisa M.

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Extracellular vs Intracellular Delivery of CO: Does It Matter for a Stable, Diffusible Gasotransmitter?

机译：细胞外与CO的细胞外递送：是否对稳定的，扩散的汽油反演是重要的？

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Carbon monoxide (CO) is a gasotransmitter produced in humans. An essential unanswered question in the design of carbon monoxide releasing molecules (CORMs) is whether the delivery molecule should be localized extra- or intracellularly to produce desired biological effects. Herein we show that extracellular CO release is less toxic and is sufficient to produce an anti-inflammatory effect similar to that of intracellular CO release at nanomolar concentrations. This information is valuable for the design of CORMs.

机译：一氧化碳（CO）是在人类中产生的汽油转体。一氧化碳释放分子（肝脏）设计中的重要未答复问题是递送分子是否应局部或细胞内局部地产生所需的生物效应。在此表明细胞外Co释放毒性较小，并且足以产生与纳米摩尔浓度的细胞内Co释放类似的抗炎作用。这些信息对于蜗虫的设计是有价值的。

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来源
《Journal of Medicinal Chemistry》 |2019年第21期|共6页
作者
Soboleva Tatiana; Simons Casey R.; Arcidiacono Ashley; Benninghoff Abby D.; Berreau Lisa M.;
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作者单位

Utah State Univ Dept Chem &

Biochem Logan UT 84322 USA;

Utah State Univ Dept Chem &

Biochem Logan UT 84322 USA;

Florida State Univ Dept Chem &

Biochem Tallahassee FL 32306 USA;

Utah State Univ Dept Anim Dairy &

Vet Sci Logan UT 84322 USA;

Utah State Univ Dept Chem &

Biochem Logan UT 84322 USA;

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正文语种 eng
中图分类药学;
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Extracellular vs Intracellular Delivery of CO: Does It Matter for a Stable, Diffusible Gasotransmitter?

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