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首页> 外文期刊>Journal of Medicinal Chemistry >Aggregation-Induced Emission Photosensitizers: From Molecular Design to Photodynamic Therapy
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Aggregation-Induced Emission Photosensitizers: From Molecular Design to Photodynamic Therapy

机译：聚集诱导的发射光敏剂：从分子设计到光动力治疗

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摘要

Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment option for cancers and other diseases. The key factor that determines the effectiveness of PDT is the photosensitizers (PSs). Upon light irradiation, the PSs would be activated, produce reactive oxygen species (ROS), and induce cell death. One of the challenges is that traditional PSs adopt a large flat disc-like structure, which tend to interact with the adjacent molecules through strong p-p stacking that reduces their ROS generation ability. Aggregation-induced emission (AIE) molecules with a twisted configuration to suppress strong intermolecular interactions represent a new class of PSs for image-guided PDT. In this Miniperspective, we summarize the recent progress on the design rationale of AIE-PSs and the strategies to achieve desirable theranostic applications in cancers. Subsequently, approaches of combining AIE-PS with other imaging and treatment modalities, challenges, and future directions are addressed.
机译：光动力疗法（PDT）已成为癌症和其他疾病的有希望的非侵入性治疗选择。确定PDT的有效性的关键因素是光敏剂（PSS）。在光照射时，PSS将被激活，产生活性氧物质（ROS），并诱导细胞死亡。其中一个挑战是传统的PSS采用大型扁平盘状结构，这倾向于通过强大的P-P堆叠与相邻分子相互作用，这降低了其ROS生成能力。具有扭曲构型的聚集诱导的发射（AIE）分子抑制强分子间相互作用的新类别的PSS，用于图像引导的PDT。在这种小型过程中，我们总结了最近的AIE-PSS设计理由的进展以及在癌症中实现所需的治疗疗法的策略。随后，解决了与其他成像和治疗方式，挑战和未来方向组合AIE-PS的方法。

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  • 来源
    《Journal of Medicinal Chemistry》 |2020年第5期|共17页
  • 作者

    Dai Jun; Wu Xia; Ding Siyang; Lou Xiaoding; Xia Fan; Wang Shixuan; Hong Yuning;

  • 作者单位

    Huazhong Univ Sci &

    Technol Tongji Hosp Tongji Med Coll Dept Obstet &

    Gynecol Wuhan 430030 Peoples R China;

    China Univ Geosci Fac Mat Sci &

    Chem Minist Educ Engn Res Ctr Nanogeomat Wuhan 430074 Peoples R China;

    La Trobe Univ La Trobe Inst Mol Sci Dept Chem &

    Phys Melbourne Vic 3086 Australia;

    China Univ Geosci Fac Mat Sci &

    Chem Minist Educ Engn Res Ctr Nanogeomat Wuhan 430074 Peoples R China;

    China Univ Geosci Fac Mat Sci &

    Chem Minist Educ Engn Res Ctr Nanogeomat Wuhan 430074 Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Hosp Tongji Med Coll Dept Obstet &

    Gynecol Wuhan 430030 Peoples R China;

    La Trobe Univ La Trobe Inst Mol Sci Dept Chem &

    Phys Melbourne Vic 3086 Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
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