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首页> 外文期刊>Journal of Molecular Biology >The Continuing Mystery of Lipid Rafts
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The Continuing Mystery of Lipid Rafts

机译：脂肪筏的持续神秘

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摘要

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a tremendous amount of attention and interest and nearly as much controversy. The controversy is perhaps surprising because the notion itself is intuitive: compartmentalization in time and space is a ubiquitous theme at all scales of biology, and therefore, the partitioning of cellular membranes into lateral subdivision should be expected. Nevertheless, the physicochemical principles responsible for compartmentalization and the molecular mechanisms by which they are functionalized remain nearly as mysterious today as they were two decades ago. Herein, we review recent literature on this topic with a specific focus on the major open questions in the field including: (1) what are the best tools to assay raft behavior in living membranes? (2) what is the function of the complex lipidome of mammalian cells with respect to membrane organization? (3) what are the mechanisms that drive raft formation and determine their properties? (4) how can rafts be modulated? (5) how is membrane compartmentalization integrated into cellular signaling? Despite decades of intensive research, this compelling field remains full of fundamental questions. (C) 2016 Elsevier Ltd. All rights reserved.
机译：自近20年前的初始形式化以来，脂筏的概念产生了巨大的关注和兴趣，几乎与争议几乎一样争议。争议可能是令人惊讶的，因为概念本身是直观的：时间和空间的舱室化是在所有生物学中的普遍存在的主题，因此，应该预期将细胞膜分配到横向细分中。然而，负责分区化的物理化学原理和它们的官能化的分子机制今天几十年前几乎是神秘的。在此，我们审查了最近关于这个主题的文献，特别关注了该领域的主要开放问题，包括：（1）在活膜中测定筏子行为的最佳工具是什么？ （2）哺乳动物细胞复杂脂质体相对于膜组织的功能是什么？ （3）驱动筏地层并确定其性质的机制是什么？ （4）如何调制筏？ （5）如何集成到蜂窝信号传导中的膜隔间化如何？尽管几十年的密集研究，但这种引人注目的领域仍然充满了基本问题。 （c）2016 Elsevier有限公司保留所有权利。

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