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首页> 外文期刊>Biosciences Biotechnology Research Asia >Azadirachta indica as a Source for Antioxidant and Cytotoxic Polyphenolic Compounds
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Azadirachta indica as a Source for Antioxidant and Cytotoxic Polyphenolic Compounds

机译：印度印za作为抗氧化剂和细胞毒性多酚化合物的来源

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Cancer is a life threatening malignant tumor, caused by many factors including the oxidative stress. Medicinal plants containing phenolic compounds represent an important source of antioxidant and anticancer drugs. Azadirachta indica Family: Meliaceaecontains variety of bioactive components of numerous biological and pharmacological properties. This study explored the constitutive polyphenols of Azadirachta indica (A. indica) growing in KSA and evaluated its antioxidant and cytotoxic activity. Chemical structures of the isolated compounds from the leaves of A. indica were established by spectral techniques (UV, MS, 1H, and "C NMR, and two dimentional NMR). The colourimetric assay (SRB) used to evaluate the cytotoxicity against HCT]]B, MCF7 and Hep-G2 cell lines. Chromatographic separation of 80% Ethanol extract of the leaves of A. indica have resulted in seven polyphenolic compounds three of them isolated for the first time from this species (2,3-(SJ-hexahydroxydiphenoyl-(a/P)-D-glucopyranose, Avicularin and Castalagin) and four known previously isolated compounds (Gallic acid, Ellagic acid, Quercetin and Quercetin-3-O-glucoside). The 80% Ethanol extract exhibited higher antioxidant activity than the ethyl acetate and butanol extracts, which is correlated with its phenolic content. The ethanolic extract, compounds 4 and 6 exhibited cytotoxic activity against HCT116, MCF7 and Hep-G2. These findings revealed that the leaves of A. indica contains a considerable amount of polyphenolic compounds withsignificant antioxidant and cytotoxic activity, consequently it could be considered as a great potential source for natural health products.
机译：癌症是威胁生命的恶性肿瘤，由多种因素引起，包括氧化应激。含有酚类化合物的药用植物是抗氧化剂和抗癌药物的重要来源。印（Azadirachta indica）家族：ia科含有多种具有多种生物学和药理特性的生物活性成分。本研究探索了在KSA中生长的印za（A. indica）的组成型多酚，并评估了其抗氧化和细胞毒性活性。通过光谱技术（UV，MS，1H和“ C NMR，以及二维NMR”）建立了从印度。草叶片中分离出的化合物的化学结构。比色法（SRB）用于评估对HCT的细胞毒性] ] B，MCF7和Hep-G2细胞系。通过色谱分离印度。草叶片中80％的乙醇提取物，得到了7种多酚化合物，其中三种首次从该物种中分离出来（2,3-（SJ-六羟基二苯甲酰基-（a / P）-D-吡喃葡萄糖，Avicularin和Castalagin）和四种已知的先前分离的化合物（苹果酸，鞣花酸，槲皮素和槲皮素-3-O-葡萄糖苷）。80％乙醇提取物的抗氧化活性高于乙醇提取物，化合物4和6对HCT116，MCF7和Hep-G2表现出细胞毒活性，这些发现表明印度A草的叶子中含有大量的HCT116，MCF7和Hep-G2。息肉烯醇化合物具有显着的抗氧化剂和细胞毒性活性，因此可以认为是天然保健产品的重要潜在来源。

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