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首页> 外文期刊>Journal of Neurophysiology >Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea
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Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea

机译：不同化学屈服压力对呼吸暂停期间交感神经招生策略的影响

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We sought to examine the effect of varying chemoreflex stress on sympathetic neural recruitment strategies during end-expiratory apnea. We hypothesized that increases in the firing frequency and probability of low-threshold axons at the asphyxic "break point" would be exaggerated during hypoxia and attenuated during hyperoxia. Multi-unit muscle sympathetic nervous system activity (MSNA) (peroneal nerve microneurography) was measured in 10 healthy male subjects (31 +/- 2 yr, 25 +/- 1 kg/m(2)). Individuals completed maximal voluntary end-expiratory apnea under normoxic, hypoxic (inspired O-2 fraction: 0.17 +/- 0.01), and hyperoxic (inspired O-2 fraction: 0.92 +/- 0.03) conditions. Action potential (AP) patterns were examined from the filtered raw signal with wavelet-based methodology. Multiunit MSNA was increased (P 0.05). We conclude that increases in frequency and incidence of APs during apnea are potentiated during hypoxia and suppressed when individuals are hyperoxic, highlighting the important impact of chemoreflex stress in AP discharge patterns. The results may have implications for neural control of the circulation in recreational activities and/or clinical conditions prone to apnea.
机译：我们试图在止血呼吸暂停期间探讨不同化学屈服应力对同情神经招生策略的影响。我们假设在缺氧期间夸大次氧化和低阈值轴突的烧制频率和低阈值轴突的概率增加，并在高血压期间衰减。多单位肌肉交感神经系统活性（MSNA）（MSNA）（腓骨神经微术）在10名健康男性受试者中测量（31 +/- 2 Yr，25 +/- 1 kg / m（2））。个人在常氧，缺氧（灵感O-2分数：0.17 +/- 0.01）下完成最大的自愿末期呼吸暂停呼吸暂停，高氧（启发O-2分数：0.92 +/- 0.03）条件。从基于小波的方法的过滤的原始信号检查动作电位（AP）模式。 Multiunit MSNA增加（p 0.05）。我们得出结论，在缺氧期间呼吸暂停期间APS的频率和发病率的增加，并且当个体过氧时抑制，突出了化学屈服应力在AP放电模式中的重要影响。结果可能对娱乐活动中循环的神经控制和呼吸呼吸暂停的临床病症有影响。

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