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首页> 外文期刊>Current pharmaceutical design >Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement.
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Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement.

机译：低度炎症是与年龄有关的疾病的常见病因分母：抗衰老策略和成功实现衰老的新型药物靶标。

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摘要

Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade systemic inflammation characterizes ageing and that inflammatory markers are significant predictors of mortality in old humans. This pro-inflammatory status of the elderly underlies biological mechanisms responsible for physical function decline and age-related diseases such as Alzheimer's disease and atherosclerosis are initiated or worsened by systemic inflammation. Understanding of the ageing process should have a prominent role in new strategies for extending the health old population. Accordingly, as extensively discussed in the review and in the accompanying related papers, investigating ageing pathophysiology, particularly disentangling age-related low grade inflammation, is likely to provide important clues about how to develop drugs that can slow or delay ageing.
机译：如今，人们的寿命比以前更长了，但是他们没有老龄化的可能。衰老是影响所有细胞，组织，器官和个人的不可逾越的内在过程，是由于动态平衡减少和机体脆弱增加导致的成熟后过程，导致对环境刺激的反应减少，并且通常是与疾病和死亡的易感性增加有关。然而，由于传染性，心血管和癌症疾病导致的高死亡率是这些病理学的共同特征，其特征在于指导性免疫和先天性免疫的失调。多项研究表明，低度全身性炎症是衰老的特征，而炎症标志物是老年人死亡率的重要预测指标。老年人的这种促炎状态是导致身体机能下降的生物学机制的基础，全身性炎症会引发或加重与年龄相关的疾病，例如阿尔茨海默氏病和动脉粥样硬化。对衰老过程的理解应该在扩展健康老龄人口的新策略中扮演重要角色。因此，正如本综述及相关相关论文中广泛讨论的那样，研究衰老的病理生理学，尤其是消除与年龄相关的低度炎症，可能会为如何开发可延缓或延迟衰老的药物提供重要线索。

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