Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections

LLopis Benoit; Funck-Brentano Christian; Tissot Nadine; Bleibtreu Alexandre; Jaureguiberry Stephane; Fourniols Eric; Aubry Alexandra; Zahr Noel

首页> 外文期刊>Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis >Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections

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Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections

机译：UPLC-MS / MS方法的开发和验证用于同时定量左氧氟沙星，环丙沙星，Moxifloxacin及人血浆中利福平的方法：应用于骨质骨质感染治疗药物监测

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Background: Fluoroquinolones and rifampicin are antibiotics frequently used for the treatment of osteoarticular infections, and their therapeutic drug monitoring is recommended. The aim of this study was to develop and validate a rapid and selective method of simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin with short pretreatment and run times in order to be easily used in clinical practice.

机译：背景：氟代喹啉和利福平是常用于治疗骨质性感染的抗生素，并建议治疗药物监测。本研究的目的是开发和验证一种快速和选择性的方法，即同时定量左氧氟沙星，环氟氯丙嘧啶，莫西沙星和利福平的短预处理和运行时间，以便在临床实践中使用。

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来源
《Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis》 |2020年第1期|共8页
作者
LLopis Benoit; Funck-Brentano Christian; Tissot Nadine; Bleibtreu Alexandre; Jaureguiberry Stephane; Fourniols Eric; Aubry Alexandra; Zahr Noel;
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作者单位

Hop La Pitie Salpetriere AP HP Dept Pharmacol CIC 1421 F-75013 Paris France;

Hop La Pitie Salpetriere AP HP Dept Pharmacol CIC 1421 F-75013 Paris France;

Hop La Pitie Salpetriere AP HP Dept Pharmacol CIC 1421 F-75013 Paris France;

Hop La Pitie Salpetriere AP HP Ctr Immunol &

Malad Infect Paris Serv Malad Infect &

Med Trop Ctr;

Hop La Pitie Salpetriere AP HP Ctr Immunol &

Malad Infect Paris Serv Malad Infect &

Med Trop Ctr;

Hop La Pitie Salpetriere AP HP Dept Orthopedia Paris France;

Sorbonne Univ Ctr Immunol &

Malad Infect Paris Natl Reference Ctr Mycobacteria Lab Bacteriol Hyg;

Hop La Pitie Salpetriere AP HP Dept Pharmacol CIC 1421 F-75013 Paris France;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Liquid chromatography; Mass spectrometry; Therapeutic drug monitoring; Antibiotics; Osteoarticular infections;

机译：液相色谱;质谱;治疗药物监测;抗生素;骨质骨质感染;

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1. Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections [J] . LLopis Benoit, Funck-Brentano Christian, Tissot Nadine, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2020,第1期

机译：UPLC-MS / MS方法的开发和验证用于同时定量左氧氟沙星，环丙沙星，Moxifloxacin及人血浆中利福平的方法：应用于骨质骨质感染治疗药物监测
2. Development and clinical validation of a simple and fast UPLC-ESI-MS/MS method for simultaneous quantification of nine kinase inhibitors and two antiandrogen drugs in human plasma: Interest for their therapeutic drug monitoring [J] . Llopis Benoit, Robidou Pascal, Tissot Nadine, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2021,第1期

机译：一种简单快速的UPLC-ESI-MS / MS方法的开发和临床验证，用于同时定量九酶抑制剂和人血浆中两种抗衰老药物的方法：对其治疗药物监测的兴趣
3. Development and validation of an UPLC-MS/MS bioanalytical method for simultaneous quantification of the antiretroviral drugs dolutegravir, elvitegravir, raltegravir, nevirapine and etravirine in human plasma [J] . Bollen Pauline D. J., de Graaff-Teulen Marga J. A., Schalkwijk Stein, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2019,第期

机译：UPLC-MS / MS生物分析方法的开发和验证用于同时定量抗逆转录病毒药物Dolututgravir，Elvitegravir，Raltegravir，Nevirapine和etravirine的人血浆
4. EFFICIENT PHOSPHOLIPIDS REMOVING CLEAN-UP SPE-LC-MS/MS METHOD FOR SIMULTANEOUS PLASMA QUANTIFICATION OF 11 TYROSINE KINASE INHIBITORS AND CAFFEINE. APPLICATION TO THERAPEUTIC DRUG MONITORING [C] . Dora Koller, Viktoryia Vaitsekhovich, Cecile Mba, International Mass Spectrometry Conference . 2018

机译：高效磷脂去除清洁SPE-LC-MS / MS法，用于同时血浆定量11酪氨酸激酶抑制剂和咖啡因。应用于治疗药物监测
5. Validation of a UPLC-MS/MS method for the simultaneous measurement of the antiretroviral drugs atazanavir, darunavir, efavirenz, etravirine, lopinavir, raltegravir, ritonavir from human plasma. [D] . Patel, Rutva. 2012

机译：用于从人血浆中同时测定抗逆转录病毒药物阿扎那韦，达鲁那韦，依非韦伦，依曲韦林，洛匹那韦，拉格列韦，利托那韦的UPLC-MS / MS方法的验证。
6. Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma: Clinical Application to Therapeutic Drug Monitoring [O] . Naser F. Al-Tannak, Ahmed Hemdan, Maya S. Eissa 2018

机译：同时测定人血浆中索非布韦和达卡他韦新组合的鲁棒性UPLC方法的开发：在治疗药物监测中的临床应用
7. Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections [O] . Benoit LLopis, Christian Funck-Brentano, Nadine Tissot, 2020

机译：UPLC-MS / MS方法的开发和验证用于同时定量左氧氟沙星，环丙沙星，Moxifloxacin及人血浆中利福平的方法：应用于骨质骨质感染治疗药物监测

Development and validation of a UPLC-MS/MS method for simultaneous quantification of levofloxacin, ciprofloxacin, moxifloxacin and rifampicin in human plasma: Application to the therapeutic drug monitoring in osteoarticular infections

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