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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >Cold atmospheric plasma-induced acidification of tissue surface: visualization and quantification using agarose gel models
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Cold atmospheric plasma-induced acidification of tissue surface: visualization and quantification using agarose gel models

机译：冷大气等离子体诱导组织表面的酸化：使用琼脂糖凝胶模型可视化和定量

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摘要

The biological effects induced by cold atmospheric plasmas (CAPs) on human tissues are mainly due to the production of reactive oxygen and nitrogen species (RONS). Some RONS are also responsible for pH lowering of the treated medium. The CAP-induced acidification has beneficial effect on biological tissues, contributing to the anti-bacterial effect and to the healing improvement observed in treated wound. In this work we investigated the local acidification induced by a helium CAP treatment using tissue models made of agarose gels with adjusted pH around 7.4 to mimic generic organs or around 5.5 to simulate skin surface pH. Using fluorescein as a pH-sensitive fluorescent marker, we developed a useful technique to visualize and quantify the local acidification induced by CAP exposure of tissue surface. The different capillaries used to produce the plasma jet, the treatment time, the initial pH of the surface and the buffer capacity of the tissue model were shown to modulate both the size of the impacted surface and the intensity of the pH decrease. The proposed technique can be advantageous to study the acidifying effect induced by plasma. This method can help to plan safe and controlled plasma treatments in order to avoid hyper-acidification of the tissue, especially when a localized treatment is administered.
机译：冷大气压素（帽）对人组织诱导的生物学效应主要是由于产生反应性氧和氮物质（rons）。一些rons也负责pH降低治疗介质。纤维诱导的酸化对生物组织有益效果，有助于抗细菌效应和治疗伤口中观察到的愈合改善。在这项工作中，我们研究了使用由琼脂糖凝胶制成的组织模型来研究氦帽治疗诱导的琼脂糖凝胶，其调节的pH值为7.4，以模拟通用器官或约5.5以模拟皮肤表面pH。使用荧光素作为pH敏感的荧光标记物，我们开发了一种可视化和量化组织表面暴露诱导的本地酸化的有用技术。示出了用于产生等离子体射流的不同毛细管，处理时间，表面模型的初始pH和组织模型的缓冲容量，调节撞击表面的尺寸和pH的强度降低。所提出的技术可以有利于研究等离子体诱导的酸化效果。该方法可以有助于规划安全和可控的血浆处理，以避免组织的超酸化，特别是当施用局部处理时。

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