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首页> 外文期刊>Biosciences Biotechnology Research Asia >Prevalence of hopQ Alleles and Relationship between cagA and vacA si with hopQ I Gene in Helicobacter pylori Strains Isolated from Patients with Peptic Ulcer Referred to Towhid Hospital in Sanandaj (2014)
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Prevalence of hopQ Alleles and Relationship between cagA and vacA si with hopQ I Gene in Helicobacter pylori Strains Isolated from Patients with Peptic Ulcer Referred to Towhid Hospital in Sanandaj (2014)

机译：从Sanandaj Towhid医院转诊的消化性溃疡患者中分离出的幽门螺杆菌菌株中hopQ等位基因的流行率以及cagA和vacA si与hopQ I基因的关系（2014）

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摘要

Infection with H. pylori leads to digestive diseases including gastritis, peptic ulcer, and gastric adenocarcinoma. The virulence factors of H. pylori outer membrane proteins or Hop [Helicobacter pylori outer membrane protein) as an auto transporter and has widely adhesion properties, phase changes and recombination. H. pylori genome is widely encoded HopQ [Helicobacter pylori outer membrane protein Q), which affect the strains of H. pylori binding to human epithelial cells. The aim of this study determine the prevalence of hopQ alleles and associated Between cagA and vacA si with hopQ I gene in H. pylori strains isolated from patients with peptic ulcer referred to Towhid Hospital in Sanandaj (2014). Biopsy specimens from 100 patients with peptic ulcer H. pylori positive were collected and separated, different allele hopQ, vacA, cagA by PCR (Polymerase Chain reaction) was determined. The relationship between genes, cagA and vacA si hopQ I with Chi-square test SPSS version 20 (version 19, SPSS Inc.,Chicago, IL) was used. P value <0.05 was considered as significant. The frequency of genes hopQ I, hopQII, cagA, vacA si, vacA s2, respectively, 54 (54%), 46 (46%), 51 (51%), 83 (83%), 17 (17 %). The relationship between hopQ I and cagA (P<0.01), hopQ Iand vacA si (P<0.026), respectively. In this study, the presence of the CagA and hopQ I, HopQ I and VacA SI gene in patients with gastric ulcer statistically significant relationship was found.
机译：幽门螺杆菌感染会导致消化系统疾病，包括胃炎，消化性溃疡和胃腺癌。幽门螺杆菌外膜蛋白或Hop（幽门螺杆菌外膜蛋白）作为自转运蛋白的毒力因子，具有广泛的粘附特性，相变和重组。幽门螺杆菌基因组是广泛编码的HopQ（幽门螺杆菌外膜蛋白Q），它影响幽门螺杆菌与人上皮细胞结合的菌株。这项研究的目的是确定分离自消化性溃疡患者的幽门螺杆菌菌株中hopQ等位基因的流行率，以及cagA和vacA si与hopQ I基因之间的相关性，并转介给Sanandaj的Towhid医院（2014年）。收集并分离100例消化性溃疡幽门螺杆菌阳性患者的活检标本，通过PCR（聚合酶链反应）确定不同的等位基因hopQ，vacA，cagA。使用卡方检验SPSS 20版（版本19，SPSS Inc.，芝加哥，伊利诺伊州）使用cagA和vacA si hopQ I基因之间的关系。 P值＜0.05被认为是显着的。基因hopQ I，hopQII，cagA，vacA si和vacA s2的频率分别为54（54％），46（46％），51（51％），83（83％），17（17％）。 HopQ I和cagA（P <0.01），hopQ I和vacA si（P <0.026）之间的关系分别。在这项研究中，发现胃溃疡患者中存在CagA和hopQ I，HopQ I和VacA SI基因具有统计学意义。

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