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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Distal airway function assessed by oscillometry at varying respiratory rate: comparison with dynamic compliance.
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Distal airway function assessed by oscillometry at varying respiratory rate: comparison with dynamic compliance.

机译：通过示波法在不同的呼吸频率下评估远端气道功能：与动态顺应性比较。

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Distal airways disease causes significant morbidity yet remains insufficiently identified. We hypothesize that: ( [1] ) when spirometry is normal impulse oscillometry may provide information about mechanical properties of the distal airways in a manner comparable to dynamic compliance and ( [2] ) variation of breathing frequency will influence oscillometric measurements similar to effects of breathing frequency on dynamic compliance. Fifty-three symptomatic subjects with normal large airway function (spirometry) were studied; distal airway dysfunction was identified by presence of frequency dependence of compliance (FDC). Oscillometric parameters evaluated were resistance at 20 Hz (R20) and 5-20 Hz (R(5-20)), reactance at 5 Hz (X5), and reactance area (AX). R20 correlated with airway resistance by esophageal manometry (r = 0.74, p < 0.001); X5 correlated with dynamic compliance at a respiratory rate of 60 bpm (r = 0.61, p < 0.001); R(5-20) and AX correlated with FDC (r = 0.48, p < 0.001; r = 0.53, p < 0.01). IOS indices were further evaluated at increased respiratory rate (RR40). Oscillometric parameters changed minimally at RR40 in normal subjects DeltaR20 = 0.20 +/- 0.08 cmH2O/L/s, DeltaR(5-20) = 0.10 +/- 0.03 cmH2O/L/s, DeltaAX = 0.33 +/- 0.19 cmH2O/L). However, in symptomatic subjects, while R20 increased minimally at RR40 (DeltaR20 = 0.37 +/- 0.10 cmH2O/L/s), R(5-20) and AX increased markedly (DeltaR(5-20) = 0.54 +/- 0.06 cmH2O/L/s, DeltaAX = 4.28 +/- 0.67 cmH2O/L) and reversed post bronchodilator. IOS evaluates physiology of the distal airways in a manner comparable to dynamic compliance. Elevated respiratory rate influences oscillometric parameters and must be considered when interpreting oscillometric data. IOS provides a non-invasive tool for assessment of distal airway function when spirometry is normal, which can be applied to various clinical settings including early diagnosis of COPD (GOLD stage 0), asthma in clinical remission and occupational/ environmental irritant exposure.
机译：气道远端疾病引起大量发病，但仍未得到充分鉴定。我们假设：（1）肺活量测定法为正常时，脉冲示波法可能以与动态顺应性相当的方式提供有关远端气道机械特性的信息;（2）呼吸频率的变化将影响示波法测量，类似于动态顺应性的呼吸频率。研究了53例具有正常大气道功能（肺活量测定法）的有症状受试者。通过频率依从性（FDC）识别远端气道功能障碍。评估的示波参数是20 Hz（R20）和5-20 Hz（R（5-20​​））的电阻，5 Hz的电抗（X5）和电抗面积（AX）。 R20与食管测压法与气道阻力相关（r = 0.74，p <0.001）; X5与呼吸频率为60 bpm的动态顺应性相关（r = 0.61，p <0.001）; R（5-20​​）和AX与FDC相关（r = 0.48，p <0.001; r = 0.53，p <0.01）。在呼吸频率增加（RR40）时进一步评估了IOS指数。正常受试者的RR40处的示波法参数变化最小）。但是，在有症状的受试者中，尽管R20在RR40处最小增加（DeltaR20 = 0.37 +/- 0.10 cmH2O / L / s），但R（5-20​​）和AX明显增加（DeltaR（5-20​​）= 0.54 +/- 0.06 cmH2O / L / s，DeltaAX = 4.28 +/- 0.67 cmH2O / L），并在支气管扩张剂后倒转。 IOS以与动态顺应性相当的方式评估远端气道的生理。呼吸频率升高会影响示波参数，并且在解释示波数据时必须予以考虑。当肺活量测定仪正常时，IOS提供了一种评估远端气道功能的非侵入性工具，可用于各种临床环境，包括COPD的早期诊断（GOLD 0级），临床缓解中的哮喘以及职业/环境刺激性暴露。

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