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首页> 外文期刊>Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices >A low-cost and simple paper-based microfluidic device for simultaneous multiplex determination of different types of chemical contaminants in food
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A low-cost and simple paper-based microfluidic device for simultaneous multiplex determination of different types of chemical contaminants in food

机译：一种低成本，简单的纸质微流控设备，用于同时多重测定食品中不同类型的化学污染物

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摘要

It is difficult to carry out multiple detection of different type of chemicals because of the different chemical microenvironment requirements. Herein, a low-cost and simple paper-based microfluidic device integrated with fluorescence labeled single-stranded DNA (ssDNA) functionalized graphene oxide sensor was developed for the multiplex determination of different types of chemical contaminants in food. In this work, Cy5 labeled corresponding functional ssDNA for different analytes associated with graphene oxide (ssDNA-GO) were employed as core detection sensors to sensitively report the presence of the different type of chemicals as well as enlarge the chemical compatibility, which made it possible to simultaneous detect multiple chemicals under a same chemical microenvironment Paper microfluidic device can be easily fabricated and paper substrate also facilitated the integration of ssDNA-GO sensors via physical absorption. This device has been successfully applied in multiplex detection of heavy metal mercury (II) ion (Hg2+) and silver (I) ion (Ag+) and aminoglycoside antibiotics residues in food. It also provided enormous potential for applications of environmental monitoring and clinical diagnosis. (C) 2014 Elsevier B.V. All rights reserved.
机译：由于不同的化学微环境要求，很难对多种类型的化学物质进行多次检测。在本文中，开发了一种低成本，简单的基于纸张的微流体装置，该装置集成了荧光标记的单链DNA（ssDNA）功能化的氧化石墨烯传感器，用于食品中不同类型化学污染物的多重测定。在这项工作中，使用Cy5标记的与氧化石墨烯（ssDNA-GO）相关的不同分析物的相应功能性ssDNA作为核心检测传感器，以灵敏地报告不同类型化学物质的存在并扩大化学相容性，从而使其成为可能。在同一化学微环境下同时检测多种化学物质纸微流控设备易于制造，纸质底物还通过物理吸收促进了ssDNA-GO传感器的整合。该设备已成功应用于食品中重金属汞（II）离子（Hg2 +）和银（I）离子（Ag +）以及氨基糖苷类抗生素残留的多重检测。它还为环境监测和临床诊断的应用提供了巨大的潜力。 （C）2014 Elsevier B.V.保留所有权利。

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