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首页> 外文期刊>Academic radiology >Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study.
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Carotid vulnerable lesions are related to accelerated recurrence for cerebral infarction magnetic resonance imaging study.

机译：颈动脉脆弱性病变与脑梗死磁共振成像研究的加速复发有关。

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RATIONALE AND OBJECTIVES: We sought to test the hypothesis that magnetic resonance imaging (MRI)-defined vulnerable plaques correlate to accelerated reoccurrence of cerebrovascular events and to evaluate the potential use of MRI in secondary prevention of ischemic stroke. MATERIALS AND METHODS: Fifty-three symptomatic participants were recruited from patients sustaining their second MRI-confirmed cerebral infarction. Nine participants were women and 44 were men; the mean age was 69.2 years (range, 55-94 years). Patients were imaged within 7 days after the reoccurrence of cerebral infarction. The MRI diagnostic signals defined a classification of lesion type. We compare the interval between two cerebral infarctions with plaque vulnerability defined by the MRI lesion type. We used a Cox proportional hazards model to calculate the relationship between vulnerable lesions and the interval of cerebral infarction, and we followed these patients for 180 days and compared the recurrent rate for the third-time cerebral infarction between patients with and without vulnerable plaque. RESULTS: The mean infarction recurrence interval for patients with vulnerable lesions was shorter than the mean interval for patients without vulnerable lesion (310.1 versus 1697.2, P< .001). In patients with recurrent cerebral infarction within 1 year, vulnerable lesions were more frequently detected (76% versus 19%, P< .001). The patients with vulnerable lesions had an 8.8-fold higher hazard risk (8.8; P< .001, 95% confidence interval, 3.9-19.7) than those without vulnerable lesions after adjustment for risk factors. For those with vulnerable plaque, the morbidity of third-time cerebral infarction was higher than those without (24% versus 3%, P = .023). CONCLUSION: MRI-defined vulnerable lesions in carotid arteries are related to accelerated recurrent cerebral infarction and high recurrent rate. MRI demonstrates clinical value in the secondary prevention of cerebral infarction.
机译：理由和目的：我们试图检验以下假设：磁共振成像（MRI）定义的易损斑块与脑血管事件的加速复发相关，并评估MRI在缺血性卒中的二级预防中的潜在用途。材料与方法：从患有第二次MRI证实的脑梗死的患者中招募了53名有症状的参与者。 9名参与者是妇女，44名是男性;平均年龄为69.2岁（范围为55-94岁）。脑梗死复发后7天内对患者进行成像。 MRI诊断信号定义了病变类型的分类。我们比较了两个脑梗死之间的时间间隔与斑块易损性（由MRI病变类型定义）。我们使用Cox比例风险模型计算易损病变与脑梗死间隔之间的关系，并追踪这些患者180天，比较有无斑块患者和无斑块患者第三次脑梗死的复发率。结果：易损病变患者的平均梗死复发间隔短于无易损病变患者的平均间隔（310.1对1697.2，P <.001）。在1年内复发的脑梗死患者中，更容易发现脆弱的病变（76％比19％，P <.001）。调整危险因素后，易损病变患者的危险风险比无易损病变的患者高8.8倍（8.8; P <.001，95％置信区间为3.9-19.7）。对于具有易损斑块的患者，第三次脑梗死的发病率高于未发生斑块的患者（24％比3％，P = .023）。结论：MRI定义的颈动脉易损病变与脑梗死复发加快和复发率高有关。 MRI证明对脑梗死的二级预防具有临床价值。

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