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首页> 外文期刊>Acta biomaterialia >Poly(propylene fumarate)/(calcium sulphate/beta-tricalcium phosphate) composites: preparation, characterization and in vitro degradation.
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Poly(propylene fumarate)/(calcium sulphate/beta-tricalcium phosphate) composites: preparation, characterization and in vitro degradation.

机译：聚（富马酸丙烯酯）/（硫酸钙/β-磷酸三钙）复合材料：制备，表征和体外降解。

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摘要

This study aimed to prepare a poly(propylene fumarate)/(calcium sulphate/beta-tricalcium phosphate) (PPF/(CaSO(4)/beta-TCP)) composite. We first examined the effects of varying the molecular weight of PPF and the N-vinyl pyrrolidinone (NVP) to PPF ratio on the maximum cross-linking temperature and the composite compressive strength and modulus. Then the in vitro biodegradation behaviour of PPF/(CaSO(4)/beta-TCP) composites was investigated. The effects of varying the molecular weight of PPF, the NVP/PPF ratio and the CaSO(4)/beta-TCP molar ratio on the weight loss and the composite compressive strength and modulus were examined. The cross-linking temperature, which increased with increasing molecular weight of PPF and NVP/PPF ratio, ranged from 41 to 43 degrees C for all formulations. The mechanical properties were increased by a decrease in the NVP/PPF ratio. For all formulations, the compressive strength values fell between 12 and 62 MPa, while the compressive modulus values fell between 290 and 1149 MPa. The weight loss decreased either with increasing molecular weight of PPF or with decreasing NVP/PPF ratio and CaSO(4)/beta-TCP molar ratio during degradation. The compressive strength and modulus increased with decreasing NVP/PPF ratio or decreasing CaSO(4)/beta-TCP ratio. The greatest weight loss over 6 weeks was 14.72%. For all formulations, the compressive modulus values fell between 57 and 712 MPa and the compressive strength fell between 0.5 and 21 MPa throughout 6 weeks degradation. Scanning electron microscopy and X-ray diffraction analysis of the PPF/(CaSO(4)/beta-TCP) composites demonstrated that hydroxyapatite was deposited on the surface of CaSO(4)/beta-TCP granules during degradation.
机译：这项研究旨在制备聚（富马酸丙烯酯）/（硫酸钙/β-磷酸三钙）（PPF /（CaSO（4）/β-TCP））复合材料。我们首先研究了改变PPF的分子量以及N-乙烯基吡咯烷酮（NVP）与PPF的比例对最大交联温度以及复合材料抗压强度和模量的影响。然后研究了PPF /（CaSO（4）/β-TCP）复合材料的体外生物降解行为。研究了PPF分子量，NVP / PPF比和CaSO（4）/β-TCP摩尔比的变化对重量损失以及复合材料抗压强度和模量的影响。对于所有配方，交联温度随PPF分子量和NVP / PPF比值的增加而增加，范围为41至43摄氏度。 NVP / PPF比值的降低提高了机械性能。对于所有配方，抗压强度值在12到62 MPa之间，而抗压模量值在290到1149 MPa之间。重量损失随着PPF分子量的增加或降解过程中NVP / PPF比值和CaSO（4）/β-TCP摩尔比的降低而降低。压缩强度和模量随NVP / PPF比降低或CaSO（4）/β-TCP比降低而增加。在6周内最大的体重减轻率为14.72％。对于所有配方，在整个6周的降解过程中，其压缩模量值均介于57至712 MPa之间，而压缩强度则介于0.5至21 MPa之间。 PPF /（CaSO（4）/β-TCP）复合材料的扫描电子显微镜和X射线衍射分析表明，降解过程中羟基磷灰石沉积在CaSO（4）/β-TCP颗粒的表面。

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