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首页> 外文期刊>Acta biomaterialia >Self-assembly of a swollen chitosan/chondroitin sulfate hydrogel by outward diffusion of the chondroitin sulfate chains.
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Self-assembly of a swollen chitosan/chondroitin sulfate hydrogel by outward diffusion of the chondroitin sulfate chains.

机译：通过硫酸软骨素链的向外扩散，溶胀的壳聚糖/硫酸软骨素水凝胶的自组装。

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摘要

A hydrogel constituted of chitosan (CT) and chondroitin sulfate (CS) was synthesized. In previously reported works the stochiometric ratio has been used, but in this paper an excess of CS (40% CT and 60% CS) was used because the hydrogel could be applied as a CS carrier. The hydrogel properties were investigated by differential scanning calorimetry, wide-angle X-ray scattering (WAXS), scanning electron microscopy, and high-performance liquid chromatography. Changes in the pH of the gel-surrounding liquid had a considerable effect on both the release and the molecular reorganization of CS. Furthermore, the formed hydrogel exhibited interesting parameters for use in biotechnology, such as water affinity, thermal properties and morphology upon sequential pH variation. The protonation or deprotonation of the different groups that participate in the complex formation and the coiling or uncoiling of like or unlike chains concomitant to the release of CS are believed to be the main factors affecting the hydrogel properties. CS was released mainly at pH higher than 6.5, the value of pK(aCT), and the released CS maximum fraction was approximately 0.5. The WAXS data demonstrated that the CT/CS complex in the hydrogel presented macromolecular reorganization at pHs ranging from 6 to 12.
机译：合成了由壳聚糖（CT）和硫酸软骨素（CS）组成的水凝胶。在以前报道的工作中使用了化学计量比，但是在本文中使用了过量的CS（40％CT和60％CS），因为水凝胶可以用作CS载体。通过差示扫描量热法，广角X射线散射（WAXS），扫描电子显微镜和高效液相色谱法研究了水凝胶的性质。凝胶周围液体的pH值的变化对CS的释放和分子重组都具有相当大的影响。此外，形成的水凝胶在生物技术中显示出令人感兴趣的参数，例如水的亲和力，热性质和连续的pH变化后的形态。参与配合物形成的不同基团的质子化或去质子化以及伴随CS释放的相似或不相似链的卷曲或解螺旋被认为是影响水凝胶性质的主要因素。 CS的释放主要是在pH值高于6.5，pK（aCT）的情况下进行的，释放的CS最大分数约为0.5。 WAXS数据表明，水凝胶中的CT / CS复合物在6至12的pH值下呈现大分子重组。

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