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首页> 外文期刊>Acta biomaterialia >Compliant electrospun silk fibroin tubes for small vessel bypass grafting.
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Compliant electrospun silk fibroin tubes for small vessel bypass grafting.

机译：符合标准的静电纺丝素蛋白管，用于小血管旁路移植。

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Processing silk fibroin (SF) by electrospinning offers a very attractive opportunity for producing three-dimensional nanofibrillar matrices in tubular form, which may be useful for a biomimetic approach to small calibre vessel regeneration. Bypass grafting of small calibre vessels, with a diameter less than 6mm, is performed mainly using autografts, like the saphenous vein or internal mammary artery. At present no polymeric grafts made of SF are commercially available, mainly due to inadequate properties (low compliance and lack of endothelium cells). The aim of this work was to electrospin SF into tubular structures (O=6mm) for small calibre vessel grafting, characterize the morphological, chemico-physical and mechanical properties of the electrospun SF structures and to validate their potential to interact with cells. The morphological properties of electrospun SF nanofibres were investigated by scanning electron microscopy. Chemico-physical analyses revealed an increase in the crystallinity of the structure of SF nanofibres on methanol treatment. Mechanical tests, i.e. compliance and burst pressure measurements, of the electrospun SF tubes showed that the inner pressure to radial deformation ratio was linear for elongation up to 15% and pressure up to 400 mm Hg. The mean compliance value between 80 and 120 mm Hg was higher than the values reported for both Goretex(R) and Dacron(R) grafts and for bovine heterografts, but still slightly lower than those of saphenous and umbilical vein, which nowadays represent the gold standard for the replacement of small calibre arteries. The electrospun tubes resisted up to 575+/-17 mmHg, which is more than four times the upper physiological pressure of 120 mmHg and more than twice the pathological upper pressures (range 180-220 mmHg). The in vitro tests showed a good cytocompatibility of the electrospun SF tubes. Therefore, the electrospun SF tubes developed within this work represent a suitable candidate for small calibre blood vessel replacement.
机译：通过静电纺丝加工丝素蛋白（SF）提供了一个非常诱人的机会来生产管状形式的三维纳米原纤维基质，这对于小口径血管再生的仿生方法可能很有用。直径小于6mm的小口径血管的旁路移植主要使用自体移植，例如隐静脉或乳内动脉。目前，主要由于性能不足（顺应性低和缺乏内皮细胞），尚无市售的SF制成的聚合物移植物。这项工作的目的是将SF静电纺成管状结构（O = 6mm），用于小口径血管移植，表征静电纺SF结构的形态，化学物理和机械性能，并验证其与细胞相互作用的潜力。通过扫描电子显微镜研究了静电纺SF纳米纤维的形貌特性。化学物理分析表明，在甲醇处理中，SF纳米纤维的结构结晶度增加。静电纺SF管的机械测试（即顺应性和爆破压力测量）表明，内部压力与径向变形之比在伸长率高达15％和压力高达400 mm Hg时呈线性关系。 80至120 mm Hg的平均顺应性值高于Goretex®和Dacron®移植物以及牛异种移植物的报告值，但仍略低于大隐静脉和脐静脉的水平，如今隐静脉和脐静脉代表黄金小口径动脉的替代标准。电纺管的抵抗力高达575 +/- 17 mmHg，这是120毫米汞柱的最高生理压力的四倍多，是病理上的最高压力（180-220毫米汞柱）的两倍以上。体外测试显示静电纺SF管具有良好的细胞相容性。因此，在这项工作中开发的电纺SF管代表了小口径血管置换的合适候选者。

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