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首页> 外文期刊>Acta biomaterialia >A novel furanone-modified antibacterial dental glass ionomer cement
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A novel furanone-modified antibacterial dental glass ionomer cement

机译：新型呋喃酮改性的抗菌牙科玻璃离聚物水泥

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摘要

A novel furanone derivative and a polyacid constructed from it were synthesized, characterized and formulated into experimental high strength cements. The compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the cements. The effect of human saliva and aging were investigated. The antibacterial activity against Lactobacillus sp. and cytotoxicity to human pulp cells were also evaluated. The results show that all the formulated furanone-containing cements showed antibacterial activity, with an initial reduction in CS. The effect of the furanone derivative loading was significant. Increasing loading enhanced the antibacterial activity but reduced the initial CS of the formed cements. The derivative showed antibacterial activity against both S. mutans and Lactobacillus sp. Human saliva did not affect the antibacterial activity of the cement. The cytotoxicity study with human dental pulp cells shows that the furanone-modified cement was biocompatible. A 30 day aging study indicated that the cements may have long-lasting antibacterial activity. Within the limitations of this study it appears that the experimental cement could be a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.
机译：合成了一种新型的呋喃酮衍生物和由其构成的多元酸，并进行了表征，并制成了实验性的高强度水泥。抗压强度（CS）和变形链球菌的生存力用于评估水泥的机械​​强度和抗菌活性。研究了人类唾液和衰老的影响。对乳杆菌的抗菌活性。还评估了对人牙髓细胞的细胞毒性。结果表明，所有配制的含呋喃酮的水泥均具有抗菌活性，CS含量初步降低。呋喃酮衍生物负载量的影响是显着的。增加的载荷增强了抗菌活性，但降低了所形成水泥的初始CS。该衍生物显示出对变形链球菌和乳杆菌的抗菌活性。人的唾液不影响水泥的抗菌活性。用人类牙髓细胞进行的细胞毒性研究表明，呋喃酮改性的水泥具有生物相容性。一项为期30天的老化研究表明，该水泥可能具有持久的抗菌活性。在这项研究的局限性内，由于其高的机械强度和抗菌功能，实验性水泥似乎是一种具有临床吸引力的牙齿修复剂。

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