• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient.
【24h】

Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient.

机译：镰状细胞患者单个红细胞生物力学特性的光学测量。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sickle cell disease (SCD) is characterized by the abnormal deformation of red blood cells (RBCs) in the deoxygenated condition, as their elongated shape leads to compromised circulation. The pathophysiology of SCD is influenced by both the biomechanical properties of RBCs and their hemodynamic properties in the microvasculature. A major challenge in the study of SCD involves accurate characterization of the biomechanical properties of individual RBCs with minimum sample perturbation. Here we report the biomechanical properties of individual RBCs from a SCD patient using a non-invasive laser interferometric technique. We optically measure the dynamic membrane fluctuations of RBCs. The measurements are analyzed with a previously validated membrane model to retrieve key mechanical properties of the cells: bending modulus; shear modulus; area expansion modulus; and cytoplasmic viscosity. We find that high cytoplasmic viscosity at ambient oxygen concentration is principally responsible for the significantly decreased dynamic membrane fluctuations in RBCs with SCD, and that the mechanical properties of the membrane cortex of irreversibly sickled cells (ISCs) are different from those of the other types of RBCs in SCD.
机译：镰状细胞病（SCD）的特征是在脱氧条件下红细胞（RBC）异常变形，因为它们的细长形状会导致血液循环不良。 SCD的病理生理学受RBC的生物力学特性及其在微脉管系统中的血液动力学特性的影响。 SCD研究中的主要挑战涉及如何以最小的样品扰动准确表征单个RBC的生物力学特性。在这里，我们报告使用非侵入性激光干涉技术从SCD患者的单个RBC的生物力学特性。我们光学测量红细胞的动态膜波动。用先前验证的膜模型分析测量值，以检索电池的关键机械性能：弯曲模量;弯曲模量;弯曲模量。剪切模量面积膨胀模量和细胞质粘度。我们发现在环境氧气浓度下高的细胞质粘度是造成SCD红细胞动态膜波动显着降低的主要原因，不可逆镰状细胞（ISC）膜皮质的机械特性不同于其他类型的细胞。 SCD中的RBC。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号