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首页> 外文期刊>Acta biomaterialia >Novel gradient casting method provides high-throughput assessment of blended polyester poly(lactic-co-glycolic acid) thin films for parameter optimization
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Novel gradient casting method provides high-throughput assessment of blended polyester poly(lactic-co-glycolic acid) thin films for parameter optimization

机译：新型梯度流延方法可提供高通量的聚酯聚酯（乳酸-乙醇酸共聚物）薄膜共混物以优化参数

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摘要

Pure polymer films cannot meet the diverse range of controlled release and material properties demanded for the fabrication of medical implants or other devices. Additives are added to modulate and optimize thin films for the desired qualities. To characterize the property trends that depend on additive concentration, an assay was designed which involved casting a single polyester poly(lactic-co-glycolic acid) (PLGA) film that blends a linear gradient of any PLGA-soluble additive desired. Four gradient PLGA films were produced by blending polyethylene glycol or the more hydrophobic polypropylene glycol. The films were made using a custom glass gradient maker in conjunction with a 180 cm film applicator. These films were characterized in terms of thickness, percent additive, total polymer (PLGA + additive), and controlled drug release using drug-like fluorescent molecules such as coumarin 6 (COU) or fluorescein diacetate (FDAc). Material properties of elongation and modulus were also accessed. Linear gradients of additives were readily generated, with phase separation being the limiting factor. Additive concentration had a Pearsons correlation factor (R) of >0.93 with respect to the per cent total release after 30 days for all gradients characterized. Release of COU had a near zero-order release over the same time period, suggesting that coumarin analogs may be suitable for use in PLGA/polyethylene glycol or PLGA/polypropylene glycol matrices, with each having unique material properties while allowing tuneable drug release. The gradient casting method described has considerable potential in offering higher throughput for optimizing film or coating material properties for medical implants or other devices.
机译：纯聚合物膜不能满足制造医疗植入物或其他设备所需的多种控释和材料性能要求。添加添加剂以调节和优化薄膜以获得所需的质量。为了表征取决于添加剂浓度的性能趋势，设计了一种测定方法，其中涉及流延混合任何线性PLGA可溶添加剂所需的聚酯聚乳酸-乙醇酸共聚物（PLGA）薄膜。通过将聚乙二醇或更具疏水性的聚丙二醇共混来生产四种梯度PLGA膜。膜是使用定制的玻璃梯度仪结合180厘米的薄膜涂布器制成的。这些膜的特征在于厚度，添加剂百分率，总聚合物（PLGA +添加剂）以及使用类药性荧光分子（如香豆素6（COU）或荧光素二乙酸酯（FDAc））控制的药物释放。还获得了伸长率和模量的材料特性。添加剂的线性梯度很容易产生，而相分离是限制因素。相对于所有表征的梯度，添加剂浓度在30天后相对于总释放百分率的Pearsons相关因子（R）> 0.93。在同一时间段内，COU的释放几乎为零级释放，这表明香豆素类似物可能适用于PLGA /聚乙二醇或PLGA /聚丙二醇基质，每种基质具有独特的材料特性，同时允许可调药物释放。所述的梯度流延方法在提供更高的产量以优化医疗植入物或其他设备的薄膜或涂层材料性能方面具有巨大潜力。

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