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首页> 外文期刊>Acta biomaterialia >In situ forming collagen-hyaluronic acid membrane structures: Mechanism of self-Assembly and applications in regenerative medicine
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In situ forming collagen-hyaluronic acid membrane structures: Mechanism of self-Assembly and applications in regenerative medicine

机译：原位形成胶原-透明质酸膜结构的自组装机理及其在再生医学中的应用

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Bioactive, in situ forming materials have the potential to complement minimally invasive surgical procedures and enhance tissue healing. For such biomaterials to be adopted in the clinic, they must be cost-effective, easily handled by the surgeon and have a history of biocompatibility. To this end, we report a novel and facile self-Assembling strategy to create membranes and encapsulating structures using collagen and hyaluronic acid (HA). Unlike membranes built by layer-by-layer deposition of oppositely charged biomolecules, the collagen-HA membranes described here form a diffusion barrier upon electrostatic interaction of the oppositely charged biomolecules, which is further driven by osmotic pressure imbalances. The resulting membranes have a nanofibrous architecture, a thicknesses of 130 ??m and a tensile modulus (0.59 ?? 0.06 MPa) that can increase 7-fold using carbodiimide chemistry (4.42 ?? 1.46 MPa). Collagen-HA membranes support mesenchymal stem cell proliferation and have a slow and steady protein release profile (7% at day 28), offering opportunities for targeted tissue regeneration. We demonstrate the capacity to encapsulate cells by injecting HA into the collagen solution, and enhance allograft and implant biocompatibility through a coating technique. This study describes a novel mechanism of collagen-HA membrane formation and provides the groundwork to apply these membranes in a variety of tissue engineering applications. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：具有生物活性的原位形成材料具有补充微创手术程序并增强组织愈合的潜力。为了使这种生物材料在临床上得到采用，它们必须具有成本效益，易于由外科医生处理并具有生物相容性的历史。为此，我们报告了一种新颖而简便的自组装策略，可使用胶原蛋白和透明质酸（HA）创建膜并封装结构。与通过带相反电荷的生物分子的逐层沉积而构建的膜不同，本文所述的胶原蛋白-HA膜在带相反电荷的生物分子的静电相互作用时形成扩散屏障，这进一步由渗透压失衡驱动。所得的膜具有纳米纤维结构，厚度为130 ?? m，拉伸模量（0.59≤0.06 MPa），使用碳二亚胺化学法（4.42≤1.46 MPa）可以增加7倍。胶原蛋白HA膜支持间充质干细胞增殖，并具有缓慢而稳定的蛋白质释放曲线（在第28天时为7％），为靶向组织再生提供了机会。我们展示了通过将HA注入胶原蛋白溶液来封装细胞的能力，并通过涂层技术增强了同种异体移植和植入物的生物相容性。这项研究描述了胶原HA膜形成的新机制，并为将这些膜应用于各种组织工程应用提供了基础。 ？ 2012年Acta Materialia Inc.由Elsevier Ltd.发行。保留所有权利。

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