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首页> 外文期刊>Acta biomaterialia >Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method.
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Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method.

机译：单向冷冻干燥法制备排列好的多孔明胶支架。

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摘要

Porous gelatin scaffolds with microtubule orientation structure were manufactured by unidirectional freeze-drying technology, and their porous structure was characterized by scanning electron microscopy. Scaffolds with tunable pore size and high porosity up to 98% were obtained by adjusting the concentration of the gelatin solution and crosslinking agent during the preparation process. All the porous gelatin scaffolds exhibited oriented microtubule pores, with width and length from 50 to 100 microm and 100 to 500 microm, respectively. Meanwhile, the properties of the scaffolds, such as porosity, water adsorption ability and compressive strength, were studied. In vitro enzymatic degradation results showed that the absolute weight loss of the gelatin scaffolds exhibited an increasing trend from low to high gelatin concentration used to prepare gelatin scaffolds; in vitro cell culture results indicated that the porous gelatin scaffolds were non-toxic to cartilage cells, since the cells spread and grew well.
机译：采用单向冷冻干燥技术制备了具有微管取向结构的多孔明胶支架，并通过扫描电子显微镜对其多孔结构进行了表征。通过在制备过程中调节明胶溶液和交联剂的浓度，可获得孔径可调且孔隙率高达98％的支架。所有的多孔明胶支架均表现出定向的微管孔，其宽度和长度分别为50至100微米和100至500微米。同时，研究了支架的孔隙度，吸水能力和抗压强度等性能。体外酶促降解结果表明，用于制备明胶支架的明胶支架的绝对失重表现出从低浓度到高浓度的增加趋势。体外细胞培养结果表明，多孔明胶支架对软骨细胞无毒，因为细胞可以扩散并生长良好。

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