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首页> 外文期刊>Acta biomaterialia >Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation.
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Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation.

机译：负载骨抑素的生物陶瓷刺激成骨细胞的生长和分化。

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摘要

Parathyroid hormone-related protein (PTHrP) is an important regulator of bone remodeling. Recent studies show that this protein can induce osteogenic features through its N- and C-terminal domains. Silica-based ordered mesoporous bioceramics with an SBA-15 structure - known to be bioactive and biocompatible - have recently been evaluated for their capacity to uptake and deliver L-tryptophan. This amino acid corresponds to the end position of the 107-111 domain (called osteostatin) of the native C-terminal PTHrP (107-139) fragment, whose true action in bone metabolism is still ill-defined. In the present study, we assessed some effects of the aforementioned biomaterials pressed into disks, loaded or not with osteostatin, in osteoblastic cell cultures. Our data demonstrate that both unmodified and organically modified SBA-15 loaded with this peptide increase cell growth and the expression of several osteoblastic products (alkaline phosphatase, osteocalcin, collagen, osteoprotegerin, receptor activator of nuclear factor-kappaB ligand and vascular endothelial growth factor) in osteoblastic cells. These findings support the notion that osteostatin coating confers osteogenic features to silica-based ordered mesoporous materials, which make them suitable biomaterials for bone repair.
机译：甲状旁腺激素相关蛋白（PTHrP）是骨骼重塑的重要调节剂。最近的研究表明，这种蛋白质可以通过其N和C末端结构域诱导成骨特征。最近已对具有SBA-15结构的硅基有序介孔生物陶瓷（已知具有生物活性和生物相容性）进行了评估，以了解其吸收和递送L-色氨酸的能力。此氨基酸对应于天然C末端PTHrP（107-139）片段的107-111结构域（称为骨抑制素）的末端位置，其在骨代谢中的真正作用仍不清楚。在本研究中，我们评估了成骨细胞培养物中上述生物材料压入或未装载骨抑素的椎间盘的某些作用。我们的数据表明，未修饰的SBA-15和有机修饰的SBA-15均会增加细胞生长，并增加某些成骨产物的表达（碱性磷酸酶，骨钙素，胶原蛋白，骨保护素，核因子-κB受体激活剂和血管内皮生长因子）在成骨细胞中这些发现支持这样的观点，即他汀类药物涂层赋予基于二氧化硅的有序介孔材料成骨性特征，这使其成为用于骨修复的合适生物材料。

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