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首页> 外文期刊>Acta biomaterialia >Injectable calcium phosphate cement with PLGA, gelatin and PTMC microspheres in a rabbit femoral defect.
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Injectable calcium phosphate cement with PLGA, gelatin and PTMC microspheres in a rabbit femoral defect.

机译：具有PLGA，明胶和PTMC微球的可注射磷酸钙水泥，用于兔股骨缺损。

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摘要

In this study, we investigated the in vivo degradation properties and tissue response towards injectable calcium phosphate cement (CPC) with no further addition, or calcium phosphate composite cement containing approximately 50 vol.% of microspheres. Three types of spheres were assessed, i.e. poly(lactic-co-glycolic acid) (PLGA), gelatin (GEL) and poly(trimethylene carbonate) (PTMC). The cements were injected into 4.6 mm diameter and 6mm deep cylindrical defects in the femoral condyle of New Zealand white rabbits, hardened in situ and, after wound closure, left to heal for 4, 8 and 12 weeks (n=6 for each composition and time period). After retrieval, specimens were analyzed using histological and histomorphometrical methods. Results showed that non-modified CPCs showed excellent bone contact but only very limited erosion at the surface. The CPC/PLGA implant degraded almost completely, while tissue response significantly improved at each time period. CPC/PTMC showed slower degradation characteristics compared to CPC/PLGA. Finally, at all time periods, there was an evident inflammatory response to the CPC/GEL composite cement. In conclusion, the degradation properties of the CPC/PLGA microspheres composite and its bone response when implanted into the femoral condyles of rabbits were significantly better than those of CPC/gelatin and CPC/PTMC microspheres composites.
机译：在这项研究中，我们研究了在不进一步添加或含有约50％（体积）微球的磷酸钙复合水泥的体内对注射用磷酸钙水泥（CPC）的降解性能和组织响应。评估了三种类型的球体，即聚乳酸-乙醇酸共聚物（PLGA），明胶（GEL）和聚碳酸三亚甲基酯（PTMC）。将水泥注入新西兰白兔股骨dy的4.6 mm直径和6mm深的圆柱状缺损中，在原位硬化，并在伤口闭合后愈合4、8和12周（每种组合物n = 6）。时间段）。取回后，使用组织学和组织形态计量学方法对标本进行分析。结果表明，未改性的CPC表现出优异的骨骼接触性，但表面侵蚀非常有限。 CPC / PLGA植入物几乎完全降解，而每个时间段的组织反应均明显改善。与CPC / PLGA相比，CPC / PTMC的降解特性较慢。最后，在所有时间段，对CPC / GEL复合胶结物都有明显的炎症反应。综上所述，CPC / PLGA微球复合材料植入兔股骨the时的降解性能及其骨响应显着优于CPC /明胶和CPC / PTMC微球复合材料。

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