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首页> 外文期刊>Acta biomaterialia >Fatigue and biocompatibility properties of a poly(methyl methacrylate) bone cement with multi-walled carbon nanotubes
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Fatigue and biocompatibility properties of a poly(methyl methacrylate) bone cement with multi-walled carbon nanotubes

机译：具有多壁碳纳米管的聚（甲基丙烯酸甲酯）骨水泥的疲劳和生物相容性

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摘要

Composites of multi-walled carbon nanotubes (MWCNT) of varied functionality (unfunctionalised and carboxyl and amine functionalised) with polymethyl methacrylate (PMMA) were prepared for use as a bone cement. The MWCNT loadings ranged from 0.1 to 1.0 wt.%. The fatigue properties of these MWCNT-PMMA bone cements were characterised at MWCNT loading levels of 0.1 and 0.25 wt.% with the type and wt.% loading of MWCNT used having a strong influence on the number of cycles to failure. The morphology and degree of dispersion of the MWCNT in the PMMA matrix at different length scales were examined using field emission scanning electron microscopy. Improvements in the fatigue properties were attributed to the MWCNT arresting/retarding crack propagation through the cement through a bridging effect and hindering crack propagation. MWCNT agglomerates were evident within the cement microstructure and the degree of agglomeration was dependent on the level of loading and functionality of the MWCNT. The biocompatibility of the MWCNT-PMMA cements at MWCNT loading levels upto 1.0 wt.% was determined by means of established biological cell culture assays using MG-63 cells. Cell attachment after 4 h was determined using the crystal violet staining assay. Cell viability was determined over 7 days in vitro using the standard colorimetric MTT assay. Confocal scanning laser microscopy and SEM analysis was also used to assess cell morphology on the various substrates.
机译：制备了具有多种功能（未官能化以及羧基和胺官能化）的多壁碳纳米管（MWCNT）与聚甲基丙烯酸甲酯（PMMA）的复合材料。 MWCNT的负载量为0.1至1.0重量％。这些MWCNT-PMMA骨水泥的疲劳性能在MWCNT的负载水平为0.1和0.25 wt。％时进行了表征，所用的MWCNT的类型和wt。％对破坏循环的次数有很大影响。使用场发射扫描电子显微镜检查了MWCNT在不同长度尺度下在PMMA基质中的形貌和分散程度。疲劳性能的改善归因于MWCNT通过桥接效应阻止和延缓了通过水泥的裂纹扩展并阻碍了裂纹扩展。 MWCNT团聚在水泥微结构中是明显的，团聚程度取决于MWCNT的负载水平和功能。借助于已建立的使用MG-63细胞的生物细胞培养测定法，测定了MWCNT-PMMA水泥在高达1.0重量％的MWCNT负载水平下的生物相容性。使用结晶紫染色测定法确定4小时后的细胞附着。使用标准比色MTT测定法在体外7天确定细胞活力。共聚焦扫描激光显微镜和SEM分析也用于评估各种底物上的细胞形态。

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