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首页> 外文期刊>Acta biomaterialia >Novel silk fibroin/elastin wound dressings
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Novel silk fibroin/elastin wound dressings

机译：新型丝素蛋白/弹性蛋白伤口敷料

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摘要

Silk fibroin (SF) and elastin (EL) scaffolds were successfully produced for the first time for the treatment of burn wounds. The self-assembly properties of SF, together with the excellent chemical and mechanical stability and biocompatibility, were combined with elastin protein to produce scaffolds with the ability to mimic the extracellular matrix (ECM). Porous scaffolds were obtained by lyophilization and were further crosslinked with genipin (GE). Genipin crosslinking induces the conformational transition from random coil to β-sheet of SF chains, yielding scaffolds with smaller pore size and reduced swelling ratios, degradation and release rates. All results indicated that the composition of the scaffolds had a significant effect on their physical properties, and that can easily be tuned to obtain scaffolds suitable for biological applications. Wound healing was assessed through the use of human full-thickness skin equivalents (EpidermFT). Standardized burn wounds were induced by a cautery and the best re-epithelialization and the fastest wound closure was obtained in wounds treated with 50SF scaffolds; these contain the highest amount of elastin after 6 days of healing in comparison with other dressings and controls. The cytocompatibility demonstrated with human skin fibroblasts together with the healing improvement make these SF/EL scaffolds suitable for wound dressing applications.
机译：丝素蛋白（SF）和弹性蛋白（EL）支架首次成功地用于治疗烧伤创面。 SF的自组装性能，以及出色的化学和机械稳定性以及生物相容性，与弹性蛋白结合在一起产生了具有模仿细胞外基质（ECM）能力的支架。通过冻干获得多孔支架，并将其与genipin（GE）进一步交联。 Genipin交联诱导从无规卷曲到SF链的β-折叠的构象转变，产生具有较小孔径和降低的溶胀率，降解和释放速率的支架。所有结果表明，支架的组成对其物理性质具有显着影响，并且可以容易地调节以获得适合于生物应用的支架。通过使用人类全层皮肤等效物（EpidermFT）评估伤口愈合。通过烧灼诱导标准化烧伤创面，并在50SF支架治疗的创面中获得最佳的上皮再植和最快的创面闭合。与其他敷料和对照相比，它们在愈合6天后含有最高的弹性蛋白。人皮肤成纤维细胞显示出的细胞相容性以及愈合的改善使这些SF / EL支架适合伤口敷料应用。

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