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首页> 外文期刊>Acta biomaterialia >Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering.
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Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering.

机译：用于软骨组织工程的Oligo（碳酸三亚甲基酯）-聚（乙二醇）-oligo（碳酸三亚甲基酯）三嵌段基水凝胶。

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摘要

A triblock co-polymer of oligo(trimethylene carbonate)-block-poly(ethylene glycol) 20000-block-oligo(trimethylene carbonate) diacrylate (TMC20) was used as a photo-polymerizable precursor for the encapsulation of primary articular chondrocytes. The efficacy of TMC20 as a biodegradable scaffold for cartilage tissue engineering was compared with non-degradable poly(ethylene glycol) 20000 diacrylate (PEG20) hydrogel. Chondrocytes encapsulated in PEG hydrogels containing oligo(trimethylene carbonate) (OTMC) moieties underwent spontaneous aggregation during in vitro culture, which was not observed in the PEG hydrogel counterparts. The aggregation of cells was found to be dependent on the initial cell density, as well as the mesh size of the hydrogels. Similarly, cell aggregation was also found in biodegradable PEG hydrogels containing caprolactone moieties. The aggregation of cells in TMC20 hydrogels resulted in enhanced cartilage matrix production compared with their PEG20 counterparts over 3 weeks of culture. Taken together, these results indicate that PEG hydrogels containing degradable OTMC moieties promote the aggregation and biosynthetic activity of encapsulated chondrocytes, indicating their potential as scaffolds for the repair of cartilage tissue.
机译：低聚（碳酸三亚甲基酯）-嵌段-聚（乙二醇）20000-嵌段-低聚（碳酸三亚甲基酯）二丙烯酸酯的三嵌段共聚物（TMC20）用作可光聚合的前体，用于包封初级关节软骨细胞。将TMC20作为软骨组织工程的可生物降解支架的功效与不可降解的聚（乙二醇）20000二丙烯酸酯（PEG20）水凝胶进行了比较。封装在含有低聚碳酸三亚甲基酯（OTMC）部分的PEG水凝胶中的软骨细胞在体外培养过程中自发聚集，这在PEG水凝胶对应物中没有观察到。发现细胞的聚集取决于初始细胞密度以及水凝胶的筛孔尺寸。同样，在含有己内酯部分的可生物降解的PEG水凝胶中也发现了细胞聚集。与它们的PEG20对应物相比，在3周的培养过程中，TMC20水凝胶中的细胞聚集导致软骨基质产生增加。综上所述，这些结果表明，含有可降解的OTMC部分的PEG水凝胶促进了囊化软骨细胞的聚集和生物合成活性，表明它们作为修复软骨组织支架的潜力。

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