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首页> 外文期刊>Acta biomaterialia >Nanoporous silica microparticle interaction with toll-like receptor agonists in macrophages
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Nanoporous silica microparticle interaction with toll-like receptor agonists in macrophages

机译：纳米多孔二氧化硅微粒与巨噬细胞中的toll样受体激动剂相互作用

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Nanoporous silica microparticles (NSiO 2-MP) are considered to be potential drug delivery systems and scaffolding platforms in tissue engineering. However, few biocompatibility studies regarding NSiO 2-MP interaction with the immune system have been reported. Toll-like receptors (TLR) are involved in host defence as well as autoimmune and inflammatory diseases. The results show that NSiO 2-MP up to 100 μg ml -1 do not affect macrophage cell viability after 24 h cell culture. Moreover, NSiO 2-MP do not compromise the cell viability of TLR-activated Raw 264.7 cells, for either cell surface TLR (TLR1/TLR2/TLR4/TLR6) or endocytic compartment TLR (TLR3/TLR7/TLR9). Furthermore, Raw 264.7 cells do not respond to NSiO 2-MP exposure in terms of IL-6 or IL-10 secretion. NSiO 2-MP co-treatment in the presence of TLR ligands does not impair or enhance the secretion of the pro-inflammatory cytokine IL-6 or the regulatory cytokine IL-10. Thus, NSiO 2-MP do not affect macrophage polarization towards a pro-inflammatory or immunosuppressive status, representing added value in terms of biocompatibility compared with other SiO 2-based micro- and nanoparticles.
机译：纳米多孔二氧化硅微粒（NSiO 2-MP）被认为是组织工程中潜在的药物输送系统和支架平台。然而，很少有关于NSiO 2-MP与免疫系统相互作用的生物相容性研究的报道。 Toll样受体（TLR）参与宿主防御以及自身免疫和炎性疾病。结果表明，在培养24 h后，高达100μgml -1的NSiO 2-MP不会影响巨噬细胞的生存能力。此外，对于细胞表面TLR（TLR1 / TLR2 / TLR4 / TLR6）或胞吞区TLR（TLR3 / TLR7 / TLR9），NSiO 2-MP不会损害TLR激活的Raw 264.7细胞的细胞活力。此外，就IL-6或IL-10分泌而言，Raw 264.7细胞对NSiO 2-MP暴露无反应。在TLR配体存在下进行NSiO 2-MP共同处理不会损害或增强促炎性细胞因子IL-6或调节性细胞因子IL-10的分泌。因此，NSiO 2-MP不会影响巨噬细胞向促炎或免疫抑制状态的极化，与其他基于SiO 2的微粒和纳米颗粒相比，在生物相容性方面具有附加价值。

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