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首页> 外文期刊>Acta biomaterialia >A two-scale model for simultaneous sintering and crystallization of glass-ceramic scaffolds for tissue engineering.
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A two-scale model for simultaneous sintering and crystallization of glass-ceramic scaffolds for tissue engineering.

机译：用于组织工程的玻璃陶瓷支架同时烧结和结晶的两尺度模型。

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摘要

Bioglass((R))-based glass-ceramic foams have been developed recently as highly porous, mechanically competent, bioactive and degradable scaffolds for bone tissue engineering. However, the development of the material so far has been based on a trial-and-error approach, and the existing materials are far from being optimized. In this paper, a mechanism-based model is presented for sintering deformation of Bioglass((R)) foams. The porous foams consist of struts which, in turn, consist of Bioglass((R)) particles. A corresponding two-scale model is developed based on existing viscous sintering models. Crystallization plays a key role in the sintering deformation of Bioglass((R)) foams and is taken into account in the model. Qualitative comparison between the model predictions and experimental observations is presented, showing that the model is able to capture the complicated interplay between crystallization and viscous flow during the sintering process.
机译：基于生物玻璃的玻璃陶瓷泡沫最近被开发为用于骨组织工程的高多孔性，机械性能，生物活性和可降解的支架。但是，到目前为止，该材料的开发是基于反复试验的方法，而现有材料远未得到优化。在本文中，提出了基于机理的Bioglass（R）泡沫烧结变形模型。多孔泡沫由支柱组成，而支柱又由Bioglass（R）颗粒组成。基于现有的粘性烧结模型，开发了相应的两尺度模型。结晶在Bioglass（R）泡沫的烧结变形中起关键作用，并在模型中予以考虑。模型预测和实验观察之间的定性比较表明，该模型能够捕获烧结过程中结晶与粘性流之间的复杂相互作用。

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