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首页> 外文期刊>RSC Advances >Isoliquiritigenin attenuates the invasive capacity of breast cancer cells via up-regulating the tumor suppressor RECK
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Isoliquiritigenin attenuates the invasive capacity of breast cancer cells via up-regulating the tumor suppressor RECK

机译：isoliquiritigenin通过um-promation肿瘤抑制器Reck衰减乳腺癌细胞的侵袭能力

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摘要

Breast cancer is the primary cause of cancer-related deaths in women worldwide, mainly due to tumor cell metastasis. Isoliquiritigenin (ISL), a dietary compound extracted from licorice, has been well studied for its anti-oxidant and anti-inflammatory activity, however its anti-tumor invasive capacity remains largely unknown. The RECK gene acts as a tumor suppressor due to its repressive effect on tumor cell invasion. To date, no studies have determined if ISL can induce the expression of RECK. Here, we found that ISL could efficiently attenuate the invasive capacity of breast cancer cells via up-regulating RECK protein level and down-regulating micro RNA-21 (miR-21) in a dose-and time-dependent manner. Furthermore, we firstly reported that miR-21 inhibited the expression of RECK via translation repression rather than mRNA degradation in breast cancer cells. In breast cancer cell lines MDA-MB-231 and Hs-578T exposed to ISL, restored miR-21 expression by miR-21 mimics reversed the inhibitory and inductive effects of ISL on cellular invasiveness and RECK expression, respectively. Thus, the repression of miR-21 and subsequent induction of RECK may be the anti-tumor mechanism of ISL, at least partly. The results suggest an alternative for dietary tumor intervention.
机译：乳腺癌是全世界癌症相关死亡的主要原因，主要是由于肿瘤细胞转移。 isoliquiritigenin（ISL）是一种从甘草中提取的膳食化合物，已经很好地研究了其抗氧化剂和抗炎活性，但其抗肿瘤侵袭性容量仍然很大程度上。由于对肿瘤细胞侵袭的抑制作用，Reck基因充当肿瘤抑制剂。迄今为止，如果ISL可以诱导RECK的表达，则不确定任何研究。在这里，我们发现ISL可以通过以含量和时间依赖的方式通过上调RECK蛋白水平和下调微RNA-21（miR-21）来有效地衰减乳腺癌细胞的侵入能力。此外，我们首先报道了MiR-21通过翻译抑制而不是MRNA降解在乳腺癌细胞中抑制Reck的表达。在暴露于ISL的乳腺癌细胞系MDA-MB-231和HS-578T中，MIR-21模拟物的恢复MiR-21表达分别对ISL的抑制性和感应效应分别对细胞侵袭性和RECK表达的抑制性和归纳效应。因此，对miR-21的抑制和随后的RECK诱导可以是ISL的抗肿瘤机制，至少部分地是ISL的。结果表明膳食肿瘤干预的替代方案。

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  • 来源
    《RSC Advances》 |2016年第29期|共9页
  • 作者

    Ning Shilong; Mu Juan; Shen Zhaoxia; Zhu Dongmei; Jiang Fei; Wang Xingxing; Li Yuan; Li Zhong;

  • 作者单位

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

    Nanjing Med Univ Dept Nutr &

    Food Hyg Key Lab Modern Toxicol Minist Educ Sch Publ Hlth Nanjing 211166 Jiangsu Peoples R China;

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