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首页> 外文期刊>RSC Advances >Stable isotope analysis of dietary arginine accrual and disposal efficiency in male rats fed diets with different protein content
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Stable isotope analysis of dietary arginine accrual and disposal efficiency in male rats fed diets with different protein content

机译：雄性大鼠膳食精氨酸应计和处理效率的稳定同位素分析喂养不同蛋白质含量的饮食

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摘要

The administration of diets with different protein/energy ratios induce variable but distinctive responses in rats; an excessive protein content tends to decrease fat accumulation, but reversion of this ratio tends to increase adipose tissue mass. The fate of N derived from amino acid metabolism is not only dependent on energy and dietary protein; the increased excretion of urea elicited by high-protein diets contrasts with the lower urea excretion (despite excess dietary protein and energy) in rats fed a cafeteria diet. After one month of exposure to high-protein (HPD) or cafeteria (CD) diets, we administered a gavage of N-15-arginine to undisturbed adult male rats, in order to trace the utilization of this not-recyclable-N amino acid under diets with different protein/energy relationships. Rats fed a high-protein diet excreted higher amounts of N in urine and showed much lower gastrointestinal content of the label. The CD rats decreased the excretion of urine N. Both groups' N balance showed a significant proportion of N not-accounted-for (but excreted nevertheless), the proportion being especially large in the HPD group. In conclusion, the process of disposal of amino acid N through the so far unknown pathway for "non-accounted-for N" is, thus essentially dependent on excess amino acid availability; independently of urea cycle operation and diet energy content.
机译：用不同蛋白质/能量比饮食给药诱导大鼠变量但独特的反应;过量的蛋白质含量倾向于降低脂肪积聚，但该比率的逆转趋于增加脂肪组织块。衍生自氨基酸代谢的N的命运不仅依赖于能量和膳食蛋白;通过高蛋白饮食引发的尿素排泄的增加与喂食自助餐厅饮食的大鼠尿素排泄（尽管膳食蛋白质和能量）的尿素排泄较高。在接触高蛋白（HPD）或自助餐厅（CD）饮食后，我们施用了N-15-精氨酸的饲养，未经受到的成年雄性大鼠，以追踪这种不可再循环的-N氨基酸的利用率在饮食中具有不同的蛋白质/能量关系。大鼠喂养高蛋白质饮食在尿液中排泄较高量的N，并显示出较低的标签胃肠含量。 CD大鼠降低了尿液的排泄。两组的N个平衡显示出显着比例的N不核算（但仍然排出），HPD组中的比例特别大。总之，通过该基本上未知的途径处理氨基酸N的过程基本上取决于过量的氨基酸可用性;独立于尿素周期操作和饮食能量含量。

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  • 来源
    《RSC Advances》 |2016年第73期|共8页
  • 作者

    Rotondo Floriana; Sanz Tania; Fernandez-Lopez Jose-Antonio; Alemany Mari A.; Remesar Xavier;

  • 作者单位

    Univ Barcelona Fac Biol Dept Biochem &

    Mol Med Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Biochem &

    Mol Med Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Biochem &

    Mol Med Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Biochem &

    Mol Med Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Biochem &

    Mol Med Av Diagonal 643 E-08028 Barcelona Spain;

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  • 正文语种 eng
  • 中图分类 化学;
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