Synthesis and characterization of bioreducible heparin-polyethyleneimine nanogels: application as imaging-guided photosensitizer delivery vehicle in photodynamic therapy

Debele Tilahun Ayane; Mekuria Shewaye Lakew; Lin Shuian-Yin; Tsai Hsieh-Chih

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Synthesis and characterization of bioreducible heparin-polyethyleneimine nanogels: application as imaging-guided photosensitizer delivery vehicle in photodynamic therapy

机译：生物环境肝素 - 聚乙烯亚氨基凝胶的合成与表征：在光动力疗法中的成像引导光敏剂递送载体的应用

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Herein, we synthesized and characterized novel bioreducible heparin polyethyleneimine (HPC) nanogels consisting of heparin, branched polyethyleneimine (PEI) and L-cysteine. H-1-NMR and FTIR analysis confirmed the formation of HPC nanogels while TEM and dynamic light scattering revealed uniform spherical nanoparticles with average diameter of <200 nm. Zinc phthalocyanine (ZnPC) was encapsulated via the dialysis method and the drug is released in vitro from disulfide-containing HPC nanogels in a redox-sensitive manner at low pH. Additionally, HPC nanogels possess bright blue fluorescence which eliminates the use of additional probing agent in image-guided drug delivery. Moreover, singlet oxygen detection revealed that nanogels prevented ZnPc aggregation thus enhancing O-1(2) generation and photodynamic therapy (PDT) efficacy. These results showed that disulfide crosslinked HPC nanogels are promising vehicles for stimulated photosensitizer delivery in advanced PDT.

机译：在此，我们合成并表征了由肝素，支链聚乙烯（PEI）和L-半胱氨酸组成的新型生物生产肝素聚乙烯亚胺（HPC）纳米凝胶。 H-1-NMR和FTIR分析证实了HPC纳米凝胶的形成，而TEM和动态光散射揭示了平均直径<200nm的均匀球形纳米颗粒。通过透析方法包封锌酞菁（ZnPC），并在低pH下以氧化还原敏感的方式在含二硫化物的HPC纳米凝胶中在体外释放药物。另外，HPC纳米凝胶具有明亮的蓝色荧光，可消除在图像引导药物递送中使用附加探测剂。此外，单线次氧检测显示，纳米凝胶防止ZnPC聚集，从而增强了o-1（2）产生和光动力治疗（PDT）功效。这些结果表明，二硫化物交联的HPC纳米凝胶是在高级PDT中刺激光敏剂递送的有望的载体。

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《RSC Advances》 |2016年第18期|共13页
作者
Debele Tilahun Ayane; Mekuria Shewaye Lakew; Lin Shuian-Yin; Tsai Hsieh-Chih;
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Natl Taiwan Univ Sci &

Technol Grad Inst Appl Sci &

Technol Taipei 106 Taiwan;

Natl Taiwan Univ Sci &

Technol Grad Inst Appl Sci &

Technol Taipei 106 Taiwan;

Instrument Technol Res Ctr Natl Appl Res Labs Hsinchu 300 Taiwan;

Natl Taiwan Univ Sci &

Technol Grad Inst Appl Sci &

Technol Taipei 106 Taiwan;

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正文语种 eng
中图分类化学;
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1. Synthesis and characterization of bioreducible heparin-polyethyleneimine nanogels: application as imaging-guided photosensitizer delivery vehicle in photodynamic therapy [J] . Debele Tilahun Ayane, Mekuria Shewaye Lakew, Lin Shuian-Yin, RSC Advances . 2016,第18期

机译：生物环境肝素 - 聚乙烯亚氨基凝胶的合成与表征：在光动力疗法中的成像引导光敏剂递送载体的应用
2. Synthesis and Characterization of Temperature-Sensitive and Chemically Cross-Linked Poly(N-isopropylacrylamide)/Photosensitizer Hydrogels for Applications in Photodynamic Therapy [J] . Belali Simin, Savoie Huguette, OBrien Jessica M., Biomacromolecules . 2018,第5期

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6. Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents [O] . Ting Shang, Cai-ding Wang, Lei Ren, 2013

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Synthesis and characterization of bioreducible heparin-polyethyleneimine nanogels: application as imaging-guided photosensitizer delivery vehicle in photodynamic therapy

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