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首页> 外文期刊>RSC Advances >Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model
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Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

机译：来自生物降解的PLGA微球的血管抑制素和姜黄素的双重释放抑制了小鼠模型中的刘易斯肺癌

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摘要

Lung cancer is an aggressive deadly disease worldwide. In this research, PLGA microspheres were used as a co-delivery system of angiostatin and curcumin for the synergistic treatment of lung cancer. The formulations were characterized by morphology, mean diameter, surface potential, and in vitro release kinetics. Furthermore, dual-drug loaded microspheres exhibited a higher antiproliferative activity in endothelial cells but not in HepG2 cells. More importantly, compared with single-drug loaded Ms (AS-PLGA-Ms and Cur-PLGA-Ms), dual-drug loaded Ms (As-Cur-PLGA-Ms) exhibited higher antitumor activity, which was further confirmed by the systemic histological and immunohistochemical analyses.
机译：肺癌是全世界致命的致命疾病。 在该研究中，PLGA微球被用作血管抑制素和姜黄素的共递送系统，用于肺癌的协同治疗。 通过形态，平均直径，表面电位和体外释放动力学表征制剂。 此外，双药物负载的微球在内皮细胞中表现出更高的抗增殖活性，但不在HepG2细胞中。 更重要的是，与单药负载MS（AS-PLGA-MS和Cur-PLGA-MS）相比，双药物负载MS（AS-Cur-PLGA-MS）表现出更高的抗肿瘤活性，该活性通过系统进一步证实 组织学和免疫组织化学分析。

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  • 来源
    《RSC Advances》 |2016年第112期|共7页
  • 作者

    Cao Yue; Yang Xiaoguang; Wu Yannan; Yi Jingwen; Wu Yin; Yu Chunlei; Huang Yanxin; Bao Yongli; Sun Luguo; Li Yuxin;

  • 作者单位

    Northeast Normal Univ Nat Engn Lab Druggable Gene &

    Prot Screening Jingyue St 2555 Changchun 130117 Peoples R China;

    Northeast Normal Univ Nat Engn Lab Druggable Gene &

    Prot Screening Jingyue St 2555 Changchun 130117 Peoples R China;

    Northeast Normal Univ Sch Life Sci Renmin St 5268 Changchun 130024 Peoples R China;

    Northeast Normal Univ Nat Engn Lab Druggable Gene &

    Prot Screening Jingyue St 2555 Changchun 130117 Peoples R China;

    Northeast Normal Univ Sch Life Sci Renmin St 5268 Changchun 130024 Peoples R China;

    Northeast Normal Univ Sch Life Sci Renmin St 5268 Changchun 130024 Peoples R China;

    Northeast Normal Univ Inst Genet &

    Cytol Renmin St 5268 Changchun 130024 Peoples R China;

    Northeast Normal Univ Sch Life Sci Renmin St 5268 Changchun 130024 Peoples R China;

    Northeast Normal Univ Inst Genet &

    Cytol Renmin St 5268 Changchun 130024 Peoples R China;

    Northeast Normal Univ Nat Engn Lab Druggable Gene &

    Prot Screening Jingyue St 2555 Changchun 130117 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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