One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

Palaniraja Jeyakannu; Roopan Selvaraj Mohana; Rayalu G. Mokesh

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One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

机译：通过6- endo-DIG环化的高官能化嘧啶[1,2-B]吲唑的单壶合成

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An efficient synthesis of nitrogen ring junction pyrimido-indazoles has been developed. This is a metal catalyzed transformation that proceeds via A(3) coupling reaction between 1H-indazol-3-amine, aromatic aldehydes and alkynes, which undergoes 6-endo-dig cyclization leading to the highly functionalized pyrimido[1,2-b]indazoles. Response surface methodology (RSM) was used to investigate the effect of catalyst (A(1)), reaction temperature (B-1) and time (C-1). The fluorescence quantum yields of the pyrimido[1,2-b]indazoles were calculated.

机译：已经开发出高效合成氮环连接嘧啶 - 吲唑。这是一种金属催化转化，其通过1h-吲唑-3-胺，芳香族醛和炔烃之间的（3）偶联反应进行，该氧化醛和炔烃在6- endo-DIG环化上进行，导致高官能化嘧啶[1,2-B] inazoles。响应表面方法（RSM）用于研究催化剂（A（1）），反应温度（B-1）和时间（C-1）的作用。计算嘧啶的荧光量子产率[1,2-B]吲唑。

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《RSC Advances》 |2016年第29期|共7页
作者
Palaniraja Jeyakannu; Roopan Selvaraj Mohana; Rayalu G. Mokesh;
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VIT Univ Sch Adv Sci Dept Chem Chem Heterocycles &

Nat Prod Res Lab Vellore 632014 Tamil Nadu India;

VIT Univ Sch Adv Sci Dept Chem Chem Heterocycles &

Nat Prod Res Lab Vellore 632014 Tamil Nadu India;

VIT Univ Sch Adv Sci Dept Math Vellore 632014 Tamil Nadu India;

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1. One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization [J] . Palaniraja Jeyakannu, Roopan Selvaraj Mohana, Rayalu G. Mokesh RSC Advances . 2016,第29期

机译：通过6- endo-DIG环化的高官能化嘧啶[1,2-B]吲唑的单壶合成
2. Organic-base-catalyzed diversity-oriented synthesis of novel pyrimido[1,2-b]indazole-3-carbonitrile [J] . Shinde Vijay Vilas, Jeong Yeon Tae Tetrahedron . 2016,第29期

机译：新型嘧啶并[1,2-b]吲唑-3-腈的有机碱催化多样性取向合成
3. Synthesis and structure-activity relationships of novel pyrimido(1,2-b)indazoles as potential anticancer agents against A-549 cell lines. [J] . Yakaiah T, Lingaiah BP, Narsaiah B, Bioorganic and Medicinal Chemistry Letters . 2007,第12期

机译：新型嘧啶并（1,2-b）吲唑类化合物对A-549细胞株的合成及其构效关系。
4. Synthesis of Oxindoles Using Umpolung Amination/Cyclization Reactions of 1H-Indazole-3-carboxylates [C] . Mayuko Mori, Isao Mizota, Makoto Shimizu 日本化学会春季年会講演予稿集 . 2018

机译：使用Umpolung胺化/环化反应的氧吲哚/环化反应的合成1H-吲唑-3-羧酸盐
5. Development of Tandem Reaction for Synthesis of Highly Functionalized Carbocycles [D] . Chang, Weng K. 2014

机译：串联反应合成高功能碳环的进展
6. One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo3.3.1alkenone framework [O] . Boubacar Sow, Gabriel Bellavance, Francis Barabé, 2011

机译：一锅Diels–Alder环加成/金（I）催化的6-endo-dig环化反应合成复杂的双环3.3.1烯酮骨架
7. One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework [O] . Sow, Boubacar, Bellavance, Gabriel, Barabé, Francis, 2011

机译：一锅Diels–Alder环加成/金（I）催化的6-endo-dig环化反应合成复杂的双环[3.3.1]烯酮骨架

One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

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