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Electrochemical investigations of 8-hydroxydeoxyguanosine and its determination at an edge plane pyrolytic graphite electrode

机译：8-羟基氧基胍的电化学研究及其在边缘平面热解石墨电极中的测定

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摘要

The electrochemical oxidation of 8-hydroxydeoxyguanosine (8-OHdG) has been studied at the edge plane surface of a pyrolytic graphite electrode (EPPGE) by cyclic sweep, square wave voltammetry, spectral studies, controlled potential electrolysis and related techniques. The oxidation of 8-OHdG occurred in a single well-defined peak over the entire pH range. The effect of pH revealed that the oxidation of 8-OHdG involved an equal number of electrons and protons. The 8-OHdG exhibited a linear calibration curve over a concentration range of 0.5-100 mu M and the detection limit and sensitivity are found to be 28 x 10(-9) M and 1.068 mu A mu M-1 respectively. The kinetics of the decay of the UV-absorbing intermediate generated during oxidation has been studied and the decay has been found to follow first order kinetics having a rate constant (k) in the range similar to 2.5 x 10 (3) s (1). The products of electrochemical oxidation have been characterized by using GC-MS studies. A tentative mechanism for the oxidation of 8-OHdG has also been suggested.
机译：通过循环扫描，方波伏安法，光谱研究，控制电位电解和相关技术在热解石墨电极（EPPGE）的边缘平面表面上研究了8-羟基氧基胍（8-OHDG）的电化学氧化。 8-OHDG的氧化在整个pH范围内的单个明确的峰值中发生。 pH的效果显示8-OHDG的氧化涉及相同数量的电子和质子。 8-OHDG在0.5-100 mu m的浓度范围内显示出线性校准曲线，发现检测极限和灵敏度分别为28×10（-9）m和1.068μm-1。研究了在氧化期间产生的UV吸收中间体衰减的动力学，并发现衰变遵循具有速率常数（k）的第一阶动力学在类似于2.5×10（3）的范围内（1） 。通过使用GC-MS研究表征了电化学氧化的产品。还提出了氧化8-OHDG的暂定机制。

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  • 来源
    《RSC Advances》 |2016年第3期|共7页
  • 作者

    Gupta Pankaj; Oyama Munetaka; Goyal Rajendra N.;

  • 作者单位

    Indian Inst Technol Roorkee Dept Chem Roorkee 247667 Uttar Pradesh India;

    Kyoto Univ Grad Sch Engn Dept Chem Mat Kyoto 6158520 Japan;

    Indian Inst Technol Roorkee Dept Chem Roorkee 247667 Uttar Pradesh India;

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  • 正文语种 eng
  • 中图分类 化学;
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