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Modulation of rat liver urea cycle and related ammonium metabolism by sex and cafeteria diet

机译：性别和自助餐厅饮食调节大鼠肝尿素循环及相关铵代谢

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摘要

High-energy (hyperlipidic) cafeteria diets induce insulin resistance limiting glucose oxidation, and lower amino acid catabolism. Despite high amino-N intake, amino acids are preserved, lowering urea excretion. We analysed how energy partition induced by cafeteria diet affects liver ammonium handling and urea cycle. Female and male rats were fed control or cafeteria diets for 30 days. There was a remarkable constancy on enzyme activities and expressions of urea cycle and ammonium metabolism. The key enzymes controlling urea cycle: carbamoyl-P synthase 1, arginino-succinate synthase and arginase expressions were decreased by diet (albeit more markedly in males), and their activities were correlated with the gene expressions. The effects observed, in ammonium handling enzyme activities and expressions behaved in a way similar to that of the urea cycle, showing a generalized downregulation of liver amino acid catabolism. This process was affected by sex. The different strategies of amino-N handling by females and males further modulated the preservation of 2-amino N under sufficient available energy. The effects of sex were more marked than those of diet were, since different metabolism survival strategies changed substrate partition and fate. The data presented suggest a lower than expected N flow to the liver, which overall importance for amino acid metabolism tends to decrease with both cafeteria diet and female sex. Under standard conditions, liver availability of ammonium was low and controlled. The situation was unchanged (or even lowered) in cafeteria-fed rats, ultimately depending on intestinal amino acid catabolism.
机译：高能量（高脂质化）自助餐厅饮食诱导胰岛素抵抗限制葡萄糖氧化，以及下氨基酸分解代谢。尽管高氨基-N摄入量，但保留了氨基酸，降低尿素排泄。我们分析了自助餐厅饮食的能量分区如何影响肝脏铵处理和尿素循环。女性和雄性大鼠被喂食或自助餐厅饮食30天。酶活性和尿素循环和铵代谢表达具有显着的态度。控制尿素循环的关键酶：饮食（雄性中虽然更明显）降低了氨基甲酰琥珀合酶1，阿糖氨基 - 琥珀酸盐合酶1，并且虽然更明显），其活性与基因表达相关。观察到的效果，在铵处理酶活性和表达中表现得与尿素循环的方式类似，显示肝氨基酸分解代谢的广义下调。这种过程受到性的影响。女性和男性氨基-N处理的不同策略进一步调节了在足够的可用能量下的2-氨基N的保存。由于不同的代谢生存策略改变了基板分区和命运，因此性别的影响比饮食更加明显。呈现的数据表明，对肝脏的总流量低于预期的N流，这对氨基酸代谢的总体重要性往往随着自助餐厅饮食和女性性别而减少。在标准条件下，液体的肝脏可用性低并控制。在自助餐厅喂养的大鼠中，情况不变（甚至降低），最终取决于肠氨基酸分解代谢。

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  • 来源
    《RSC Advances》 |2016年第14期|共11页
  • 作者

    Agnelli Silvia; Arriaran Soffa; Oliva Laia; Remesar Xavier; Fernandez-Lopez Jose-Antonio; Alemany Maria;

  • 作者单位

    Univ Barcelona Fac Biol Dept Nutr &

    Food Sci Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Nutr &

    Food Sci Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Nutr &

    Food Sci Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Nutr &

    Food Sci Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Nutr &

    Food Sci Av Diagonal 643 E-08028 Barcelona Spain;

    Univ Barcelona Fac Biol Dept Nutr &

    Food Sci Av Diagonal 643 E-08028 Barcelona Spain;

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  • 正文语种 eng
  • 中图分类 化学;
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