Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives

Ivanov Anton; Boldt Sebastian; un Nisa Zaib; Shah Syed Jawad Ali; Ehlers Peter; Villinger Alexander; Schneider Gyula; Woelfling Janos; Rahman Qamar; Iqbal Jamshed; Langer Peter

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Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives

机译：3-炔脲及其衍生物的合成和磷酸酶抑制活性

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A range of 3-alkynylated 3-deoxy-estrones were prepared by Sonogashira reactions and transformed into estrone derived diones and quinoxalines. The alkynylated estrones and their derivatives exhibit significant biological activity as alkaline phosphatase inhibitors. The mode of action was illustrated based on docking studies.

机译：通过Sonogashira反应制备一系列3-醇化的3-脱氧 - 雌激素，并转化为雌激素衍生的致硫酮和喹喔啉。炔基的雌酮及其衍生物表现出显着的生物活性作为碱性磷酸酶抑制剂。基于对接研究说明了作用方式。

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《RSC Advances》 |2016年第14期|共10页
作者
Ivanov Anton; Boldt Sebastian; un Nisa Zaib; Shah Syed Jawad Ali; Ehlers Peter; Villinger Alexander; Schneider Gyula; Woelfling Janos; Rahman Qamar; Iqbal Jamshed; Langer Peter;
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作者单位

Univ Rostock Inst Chem Albert Einstein Str 3a D-18059 Rostock Germany;

Univ Rostock Inst Chem Albert Einstein Str 3a D-18059 Rostock Germany;

COMSATS Inst Informat Technol Ctr Adv Drug Res Abbottabad Pakistan;

COMSATS Inst Informat Technol Ctr Adv Drug Res Abbottabad Pakistan;

Univ Rostock Inst Chem Albert Einstein Str 3a D-18059 Rostock Germany;

Univ Rostock Inst Chem Albert Einstein Str 3a D-18059 Rostock Germany;

Univ Szeged Dept Organ Chem Dom Ter 8 H-6720 Szeged Hungary;

Univ Szeged Dept Organ Chem Dom Ter 8 H-6720 Szeged Hungary;

Univ Rostock Inst Chem Albert Einstein Str 3a D-18059 Rostock Germany;

COMSATS Inst Informat Technol Ctr Adv Drug Res Abbottabad Pakistan;

Univ Rostock Inst Chem Albert Einstein Str 3a D-18059 Rostock Germany;

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正文语种 eng
中图分类化学;
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1. Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives [J] . Ivanov Anton, Boldt Sebastian, un Nisa Zaib, RSC Advances . 2016,第14期

机译：3-炔脲及其衍生物的合成和磷酸酶抑制活性
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Synthesis and phosphatase inhibitory activity of 3-alkynylestrones and their derivatives

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