Novel organotin complexes derived from 2,2 '-selenodiacetic acid: synthesis and biological evaluation

Li Qianli; Liu Xinglong; Cheng Shuang; Zhang Rufen; Shi Yang; Ma Chunlin

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Novel organotin complexes derived from 2,2 '-selenodiacetic acid: synthesis and biological evaluation

机译：衍生自2,2'-硒二乙酸的新型有机辛复合物：合成和生物学评估

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The reactions of 2,2'-selenodiacetic acid and the corresponding organotin(IV) chloride with sodiumethoxide in ethanol, or via a solvothermal synthetic route, have afforded four organotin polymers, namely, [(Me3Sn)(2)Se(CH2COO)(2)](n) (1), [(Me2Sn)(2)Se(CH2COO)(2)(mu(3)-O)](n) (2), [(Bu3Sn)(2)Se(CH2COO)(2)](n) (3), and [(Bu2Sn)Se(CH2COO)(2)](n) (4). All the complexes were fully characterized by elemental analysis, FT-IR, NMR (H-1, C-13, and Sn-119) spectroscopy and single crystal X-ray diffraction analysis. The structural analysis reveals that complex 1 is a 2D-polymer containing interconnected 24-membered (Sn4O8C10Se2) macrocyclic rings. Unlike complex 1, the 2D polymer structure of complex 2 is made up of the typical ladder tetraorganodistannoxane unit containing 32-membered (Sn4O8C16Se4) macrocyclic rings. Complex 3 is a 3D corrugated polymeric structure in which the deprotonated dicarboxylic acid acts as a tetradentate ligand by four oxygen atoms. Complex 4 is a 1D zigzag coordination polymer and the tin coordination geometry is described as skewed-trapezoidal bipyramidal. In particular, preliminary cytotoxic assessments of the involvement of complex 4 in the apoptotic death of MDA cells were conducted, and the results revealed that the antiproliferative and proapoptotic effect of complex 4 in MDA cells prominently contributed to the overload of intracellular ROS levels and the dysfunctional depolarization of mitochondrial membranes.

机译：2,2'- selenodiacetic酸并且反应在乙醇中与乙醇钠的相应有机锡（IV），氯化或通过溶剂热合成途径，已经得到4种有机锡聚合物，即，[（Me3Sn）（2）硒（CH 2 COO）（ 2）]（N）（1），[（Me2Sn）（2）硒（CH 2 COO）（2）（亩（3）-O）]（N）（2），[（Bu3Sn）（2）硒（CH2COO ）（2）]（N）（3），和[（Bu2Sn）硒（CH 2 COO）（2）]（N）（4）。所有的复合物完全表征通过元素分析，FT-IR，NMR（H-1，C-13，和Sn-119）光谱和单晶X射线衍射分析。结构分析表明，复合物1为含有互连24元（Sn4O8C10Se2）的大环环的2D-聚合物。不同于复合物1，配合物2的2D聚合物结构由含有32元（Sn4O8C16Se4）的大环环典型梯tetraorganodistannoxane单元组成。配合物3是3D波纹，其中去质子化的二羧酸作为通过四个氧原子的四齿配体的聚合结构。络合物4是一维锯齿形配位聚合物和锡配位几何形状被描述为偏斜梯形双锥。特别是，复杂的4 MDA细胞的凋亡死亡参与初步细胞毒性评估进行的，其结果表明，复杂的4 MDA细胞的抗增殖和凋亡的作用显着促进了细胞内ROS水平和功能失调的过载线粒体膜的去极化。

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《RSC Advances》 |2016年第39期|共9页
作者
Li Qianli; Liu Xinglong; Cheng Shuang; Zhang Rufen; Shi Yang; Ma Chunlin;
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Liaocheng Univ Sch Chem &

Chem Engn Liaocheng 252059 Peoples R China;

Liaocheng Univ Sch Chem &

Chem Engn Liaocheng 252059 Peoples R China;

Liaocheng Univ Sch Chem &

Chem Engn Liaocheng 252059 Peoples R China;

Liaocheng Univ Sch Chem &

Chem Engn Liaocheng 252059 Peoples R China;

Liaocheng Univ Sch Chem &

Chem Engn Liaocheng 252059 Peoples R China;

Liaocheng Univ Sch Chem &

Chem Engn Liaocheng 252059 Peoples R China;

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中图分类化学;
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Novel organotin complexes derived from 2,2 '-selenodiacetic acid: synthesis and biological evaluation

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