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Synergistic effects of hierarchical hybrid micro/nanostructures on the biological properties of titanium orthopaedic implants

机译：层次杂交微/纳米结构对钛矫形植入物生物学性质的协同作用

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摘要

A hierarchical hybrid micro/nanostructure was produced on the surface of titanium (Ti) implants by combined use of acid etching and anodic oxidation. The bioactivity of the modified Ti was evaluated by a simulated body fluid (SBF) soaking test and in vitro cell culture experiments. The results showed that the surface-modified Ti implants had a microstructure with enhanced surface roughness. There was also a nanostructure superimposed on the microstructure, forming a hierarchical hybrid micro/nanostructure. The modified Ti accelerated the Ca-P mineralization deposition on their surface in SBF, and promoted osteoblast adhesion, proliferation, and bone-related gene expression compared to the polished Ti and the Ti implants subjected only to acid etching or anodic oxidation, which was ascribed to the synergistic effects of both micro-and nanotopography generated. This study provides a simple and cost-effective approach to enhance the bioactivity and biocompatibility of orthopaedic implants, and points out the importance of both micro and nanotopography.
机译：通过组合使用酸蚀刻和阳极氧化，在钛（Ti）植入物表面上产生分层杂化微/纳米结构。通过模拟体液（SBF）浸泡试验和体外细胞培养实验评估改性Ti的生物活性。结果表明，表面改性的Ti植入物具有增强的表面粗糙度的微观结构。在微观结构上也存在纳米结构，形成分层杂交微/纳米结构。改性Ti加速了在SBF中的表面上的Ca-P矿化沉积，与抛光的Ti相比，促进了成骨细胞粘附，增殖和骨相关基因表达，并且仅对酸蚀刻或阳极氧化进行的Ti植入物进行归属对产生的微型和纳米复印件产生的协同效应。本研究提供了一种简单且经济高效的方法来提高整形外科植入物的生物活性和生物相容性，并指出微观和纳米复印件的重要性。

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  • 来源
    《RSC Advances》 |2015年第61期|共7页
  • 作者

    Li B. E.; Li Y.; Min Y.; Hao J. Z.; Liang C. Y.; Li H. P.; Wang G. C.; Liu S. M.; Wang H. S.;

  • 作者单位

    Hebei Univ Technol Sch Mat Sci &

    Engn Tianjin 300130 Peoples R China;

    Tianjin Med Univ Stomatol Hosp Tianjin 300070 Peoples R China;

    Hebei Univ Technol Sch Mat Sci &

    Engn Tianjin 300130 Peoples R China;

    Hebei Univ Technol Sch Mat Sci &

    Engn Tianjin 300130 Peoples R China;

    Hebei Univ Technol Sch Mat Sci &

    Engn Tianjin 300130 Peoples R China;

    Hebei Univ Technol Sch Mat Sci &

    Engn Tianjin 300130 Peoples R China;

    Soft Matter Nanotechnol Lab CIC BiomaGUNE Donostia San Sebastian 20009 Spain;

    Tianjin Univ Commerce Dept Gem &

    Mat Tech Tianjin 300134 Peoples R China;

    Hebei Univ Technol Sch Mat Sci &

    Engn Tianjin 300130 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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