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首页> 外文期刊>RSC Advances >A new method to determine the new C-Met inhibitor 'Cabozantinib' in dosage form and human plasma via micelle-enhanced spectrofluorimetry
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A new method to determine the new C-Met inhibitor 'Cabozantinib' in dosage form and human plasma via micelle-enhanced spectrofluorimetry

机译：一种新方法，以通过胶束增强的光谱氟化物在剂型和人血浆中测定新的C-Met抑制剂“Cabozantib”

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摘要

A highly sensitive and simple micelle-enhanced spectrofluorimetric method was developed for the determination of cabozantinib (CBZ) in its pharmaceutical formulation and spiked human plasma without any derivatization. The proposed method is based on the investigation of the fluorescence spectral behavior of CBZ in a Cremophor RH 40 (Cr RH 40) micellar system. In aqueous solution, the fluorescence intensity of CBZ was greatly enhanced (nine fold) in the presence of Cr RH 40. The fluorescence intensity was measured at 343 nm after excitation at 244 nm. The fluorescence-concentration plot was linear over the range 25-800 ng mL(-1), with a lower detection limit of 13.34 ng mL(-1). The proposed method was successfully applied to the determination of CBZ in laboratory-prepared dosage form and spiked human plasma. Recovery values of CBZ with the current method were 99.68 +/- 0.88, 100.53 +/- 0.51 and 100.44 +/- 3.91% for pure powder, lab-prepared dosage form and spiked human plasma, respectively. The results were statistically compared with those obtained by the reported chromatographic method and were found to be in good agreement.
机译：甲高度敏感和简单胶束增强荧光光谱法用于卡博替在其药物制剂的判定（CBZ）和掺料的人血浆没有任何衍生开发的。所提出的方法是基于CBZ的荧光光谱行为的在克列莫佛RH 40（CR RH 40）胶束体系的调查。在水溶液中，CBZ的荧光强度中的荧光强度在343nm处，在244处测量激发后在Cr RH 40的存在显着增强（9倍）。荧光浓度情节结束纳克mL范围25-800（-1）的线性，以每mL 13.34检测下限（-1）。所提出的方法被成功地应用于CBZ的在实验室制得的剂型和所加标人血浆的测定。与当前方法CBZ的恢复值分别为100.53 +/- 0.51和用于纯粉末，实验室制备的剂型和所加标人血浆100.44 +/- 3.91％，99.68 +/- 0.88。结果进行统计与报告的色谱法进行了比较，结果发现是很好的一致性。

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  • 来源
    《RSC Advances》 |2015年第51期|共7页
  • 作者

    Darwish Hany W.; Abdelhameed Ali S.; Bakheit Ahmed H.; Alanazi Amer M.;

  • 作者单位

    King Saud Univ Coll Pharm Dept Pharmaceut Chem Riyadh 11451 Saudi Arabia;

    King Saud Univ Coll Pharm Dept Pharmaceut Chem Riyadh 11451 Saudi Arabia;

    King Saud Univ Coll Pharm Dept Pharmaceut Chem Riyadh 11451 Saudi Arabia;

    King Saud Univ Coll Pharm Dept Pharmaceut Chem Riyadh 11451 Saudi Arabia;

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  • 正文语种 eng
  • 中图分类 化学;
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