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Chronic toxicity of crude ricinine in rats assessed by H-1 NMR metabolomics analysis

机译：H-1 NMR代谢组科分析评估大鼠粗蓖麻嗪的慢性毒性

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摘要

Ricinine is a toxic alkaloid found in the leaves and seeds of Ricinus communis L. It can cause vomiting and various other toxic reactions, including liver and kidney damage, convulsions, and hypotension, and can even lead to death. In this study, rats were orally administrated with an extract of castor bean shell ( crude ricinine) once a day for eight consecutive weeks to study its chronic toxicity. Urine, serum and kidney samples were collected and subjected to H-1 NMR metabolomics analysis. This approach, complemented by histopathological inspection and a biochemical assay, demonstrated that crude ricinine produced obvious nephrotoxicity and severe metabolic alterations in rats. These changes were related with oxidative stress, energy metabolism, amino acid metabolism, renal function and the gut bacteria system. This work provides a molecular basis for the chronic toxicity of crude ricinine and shows the power of a H-1 NMR-based metabolomic approach to study the toxicity of drugs dynamically and systematically.
机译：蓖麻氨酸是毒性的生物碱，在里尼斯的叶子和种子中发现，它会导致呕吐和各种其他有毒反应，包括肝肾损害，抽搐和低血压，甚至可以导致死亡。在这项研究中，每天持续一次蓖麻壳（粗蓖麻碱）提取物口服给予大鼠，以研究其慢性毒性。收集尿液，血清和肾脏样品并进行H-1 NMR代谢组科分析。这种方法，通过组织病理学检查和生物化学测定辅成，表明粗蓖麻嗪产生明显的肾毒性和大鼠的严重代谢改变。这些变化与氧化应激，能量代谢，氨基酸代谢，肾功能和肠道细菌系统有关。这项工作为粗蓖麻碱的慢性毒性提供了分子基础，并表明了一种基于H-1 NMR的代谢方法的力量，以便动态地和系统地研究药物的毒性。

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  • 来源
    《RSC Advances》 |2015年第34期|共11页
  • 作者

    Guo Pingping; Wei Dandan; Wang Junsong; Dong Ge; Zhang Qian; Yang Minghua; Kong Lingyi;

  • 作者单位

    China Pharmaceut Univ Dept Nat Med Chem State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Dept Nat Med Chem State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    China Pharmaceut Univ Dept Nat Med Chem State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Dept Nat Med Chem State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Dept Nat Med Chem State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Dept Nat Med Chem State Key Lab Nat Med Nanjing 210009 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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