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首页> 外文期刊>RSC Advances >In vivo targeted imaging of early stage prostate cancer using a transferrin based near-infrared fluorescence probe
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In vivo targeted imaging of early stage prostate cancer using a transferrin based near-infrared fluorescence probe

机译：使用基于转铁蛋白的近红外荧光探针在早期前列腺癌的体内靶向成像中

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摘要

Transferrin (Tf) stabilized Au nanoclusters were successfully applied in the near-infrared targeted imaging of prostate cancer overexpressing Tf receptor in vivo. The prepared Tf-Au NCs owned the merits of low cytotoxicity, good biocompatibility, and natural metabolism, excellent optical properties in the NIR region and receptor specific cancer targeting ability. In our study, serial imaging in vivo has been performed sequently. The results showed that targeted fluorescence imaging with Tf-Au NCs possessed an amazing capability of detecting the early-stage small tumours, and giving as accurate and reproducible measures of tumour size in mice as external calliper measurements. To our knowledge, this was the first time to study the biomedical application of Tf-Au NCs in vivo via intravenous administration rather than cell experiments or orthotopic injection. These remarkable data could provide direct and factual evidence that Tf-Au NCs are very promising nanoprobes which could be harmlessly and efficiently used for the targeted diagnosis of human tumours in vivo, indicating that the further clinical translation of Tf-Au NCs could be expected.
机译：转铁蛋白（Tf）稳定的Au纳米团簇在前列腺癌体内过表达TF受体的近红外靶向成像已成功应用。将制得的TF-的Au的NC拥有低细胞毒性，良好的生物相容性，和天然代谢，优异的光学性能的优点在NIR区域和受体特异性癌靶向性。在我们的研究中，在体内串行成像已经sequently执行。结果表明，与TF-的Au NC的靶向荧光成像具有检测早期小肿瘤，并给予如在小鼠中作为外部卡钳测量肿瘤大小的精确和可重复的措施的惊人能力。据我们所知，这是第一次研究TF金NC的体内经静脉给药，而不是细胞实验或原位注射生物医学应用。这些骄人的数据可以提供直接和事实的证据表明，TF-金NC之间都非常看好这可能无害而且有效地用于人体内肿瘤的靶向诊断的纳米探针，表明TF金NC的进一步的临床翻译可以预期。

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  • 来源
    《RSC Advances》 |2015年第79期|共7页
  • 作者

    Zhao Yang; Peng Jing; Niu Yuanjie; Zhang Xuening; Jiang Ning; Jia Rongrong; Li Jiang; Shang Zhiqun; Zhu Shimiao; Sun Libin;

  • 作者单位

    Tianjin Med Univ Tianjin Inst Urol Sex Hormone Res Ctr Dept Urol Hosp 2 Tianjin Peoples R China;

    Tianjin Med Univ Hosp 2 Dept Radiol Tianjin Peoples R China;

    Tianjin Med Univ Tianjin Inst Urol Sex Hormone Res Ctr Dept Urol Hosp 2 Tianjin Peoples R China;

    Tianjin Med Univ Hosp 2 Dept Radiol Tianjin Peoples R China;

    Tianjin Med Univ Tianjin Inst Urol Sex Hormone Res Ctr Dept Urol Hosp 2 Tianjin Peoples R China;

    Tianjin Med Univ Hosp 2 Dept Radiol Tianjin Peoples R China;

    Tianjin Med Univ Hosp 2 Dept Radiol Tianjin Peoples R China;

    Tianjin Med Univ Tianjin Inst Urol Sex Hormone Res Ctr Dept Urol Hosp 2 Tianjin Peoples R China;

    Tianjin Med Univ Tianjin Inst Urol Sex Hormone Res Ctr Dept Urol Hosp 2 Tianjin Peoples R China;

    Tianjin Med Univ Tianjin Inst Urol Sex Hormone Res Ctr Dept Urol Hosp 2 Tianjin Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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