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首页> 外文期刊>RSC Advances >Nitro-substituted 3,3 '-bis(indolyl)methane-modified silica gel as a sorbent for solid-phase extraction of flavonoids
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Nitro-substituted 3,3 '-bis(indolyl)methane-modified silica gel as a sorbent for solid-phase extraction of flavonoids

机译：硝基取代的3,3' -bis（吲哚基）甲烷改性硅胶作为用于固相提取的黄芪的吸附剂

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摘要

A novel solid-phase extraction (SPE) sorbent was synthesized by chemical immobilization of nitro-substituted 3,3 '-bis(indolyl) methane onto pure silica. The nitro-substituted 3,3 '-bis(indolyl) methane-modified silica was evaluated by elemental analysis (EA) and Fourier transform infrared spectroscopy (FT-IR). Coupled to high performance liquid chromatography (HPLC), the extraction performance of the sorbent was evaluated by using five flavonoids as model analytes. The results showed that the new sorbent could offer multiple intermolecular interactions, such as pi-pi, hydrophobic, and hydrogen bonding interactions. Several factors including the extraction material, sample solution pH, sample loading rate, eluent type, volume of eluent, elution rate, and volume of sample loading were optimized. Under the optimal conditions, the proposed method was applied for the analysis of five flavonoids in grape juice. Satisfactory linear ranges for flavonoids were obtained in the range of 10-200 ng mL(-1) for myricetin, 5-200 ng mL(-1) for quercetin and apigenin, and 1-200 ng mL(-1) for luteolin and kaempferol, with correlation coefficients (R) ranging from 0.9908 to 0.9996. Limits of detection (LODs) were in the range of 0.5-10 ng mL(-1). The recovery values of spiked grape juice ranged from 91.5% to 120.7% with relative standard deviations (RSDs) less than 9.12% (n = 5). As a novel solid-phase extraction sorbent, the nitro- substituted 3,3 '-modified silica exhibited a higher extraction efficiency towards the tested compounds than diol-modified silica.
机译：通过将硝基取代的3,3'-bis（吲哚基）甲烷的化学固定在纯二氧化硅上，通过化学固定化合成了一种新的固相萃取（SPE）吸附剂。通过元素分析（EA）和傅里叶变换红外光谱（FT-IR）评价硝基取代的3,3' -Bis（吲哚基）甲烷改性二氧化硅。结合高性能液相色谱（HPLC），通过使用五种黄酮类化合物作为模型分析来评估吸附剂的提取性能。结果表明，新的吸附剂可以提供多个分子间相互作用，例如PI-PI，疏水和氢键相互作用。优化了几种因素，包括提取材料，样品溶液pH，样品加载速率，洗脱液类型，洗脱液体积，洗脱率和样品载荷体积。在最佳条件下，拟议的方法用于分析葡萄汁中的五种黄酮醇。对于槲皮素，5-200 ng ml（-1）的槲皮素，5-200ng（-1）和1-200ng ml（-1）的Luteolin和1-200ng ml（-1），获得令人满意的黄酮类化合物的线性范围Kaempferol，相关系数（R）范围为0.9908至0.9996。检测限率（LOD）在0.5-10ng ml（-1）的范围内。尖刺葡萄汁的恢复值范围为91.5％至120.7％，相对标准偏差（RSD）小于9.12％（n = 5）。作为一种新型固相萃取吸附剂，硝基取代的3,3'Modified二氧化硅表现出比二醇改性二氧化硅的测试化合物更高的提取效率。

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  • 来源
    《RSC Advances》 |2015年第20期|共7页
  • 作者

    Wang Na; Liang Xiaojing; Li Qian; Liao Yuan; Shao Shijun;

  • 作者单位

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Chem Northwestern Plant Resources CAS Lanzhou 730000 Peoples R China;

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Chem Northwestern Plant Resources CAS Lanzhou 730000 Peoples R China;

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Chem Northwestern Plant Resources CAS Lanzhou 730000 Peoples R China;

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Chem Northwestern Plant Resources CAS Lanzhou 730000 Peoples R China;

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Chem Northwestern Plant Resources CAS Lanzhou 730000 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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