One-pot synthesis of functionalized isoxazole- thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

Sakkani Nagaraju; Neeli Satyanarayana; Banoth Paplal

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One-pot synthesis of functionalized isoxazole- thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

机译：通过KNOEVENAGER缩合和Domino Sulfa-1,6-迈克尔/分子内乙烯基致反应的官能化异恶唑 - 硫醇杂交物的单壶合成

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One-pot synthesis of highly functionalized tetrahydrothiophene (thi- olane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa- 1,6-Michael/intramolecular vinylogous Henry reactions of aldehydes, 1,4-dithiane-2,5-diol and 3,5-dimethyl-4-nitroisoxazole. From the base and solvent screening, it was found that piperidine (30mol%) and ethanol are the most suitable conditions giving the desired products with >95% yields in 2-2.5 h overall reaction time.

机译：通过Knoevenagel缩合报道与生物学上有用的异恶唑缀合的高官能化四氢噻吩（硫烷）衍生物的单壶合成，然后通过醛氨基磺基-1,6-迈克尔/分子内乙烯基雄性亨利反应，1,4-二岛-2 ，5-二醇和3,5-二甲基-4-硝基异恶唑。从碱和溶剂筛选中发现，哌啶（30mol％）和乙醇是最合适的条件，其优选的产物具有> 95％的产率为2-2.5小时的总反应时间。

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《RSC Advances》 |2015年第114期|共5页
作者
Sakkani Nagaraju; Neeli Satyanarayana; Banoth Paplal;
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Department of Chemistry National Institute of Technology Warangal-506 004 India.;

Department of Chemistry National Institute of Technology Warangal-506 004 India.;

Department of Chemistry National Institute of Technology Warangal-506 004 India.;

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1. One-pot synthesis of functionalized isoxazole- thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions [J] . Sakkani Nagaraju, Neeli Satyanarayana, Banoth Paplal RSC Advances . 2015,第114期

机译：通过KNOEVENAGER缩合和Domino Sulfa-1,6-迈克尔/分子内乙烯基致反应的官能化异恶唑 - 硫醇杂交物的单壶合成
2. One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions (vol 5, pg 94474, 2015) [J] . Nagaraju Sakkani, Satyanarayana Neeli, Paplal Banoth, RSC Advances . 2015,第124期

机译：通过Knoevenagel缩合和多米诺磺胺-1,6-Michael /分子内乙烯基亨利反应一锅法合成功能化的异恶唑-硫杂环戊烷杂物（第5卷，第94474页，2015）
3. Correction: One-pot synthesis of functionalized isoxazole–thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions [J] . Sakkani Nagaraju, Neeli Satyanarayana, Banoth Paplal, RSC Advances . 2015,第124期

机译：校正：通过Knoevenagel缩合和Domino Sulfa-1,6-迈克尔/分子内乙烯基致反应的单壶合成官能化异恶唑 - 硫醇杂交物
4. Synthesis of tetrahydroquinoline with site-selective C-H bondfunctionalization through intramolecular hydroarylation-redoxCDC reaction [C] . Guo Yu, Xuhai Zhang, Guangzhe Li 日本化学会春季年会 . 2020

机译：通过分子内氢化氧化铈反应合成位点选择性C-H键合结合的四氢喹啉
5. 1. Studies directed toward the synthesis of 20B-carbachaparrinone analogs via a samarium (II) iodide ring closure of a highly functionalized intermediate. 2. Synthesis of 5-oxo-cyclopent-1-enecarboxylic acid methyl esters via a novel tandem aldol-knoevenagel condensation. 3. Novel carbocyclic ring formation via intramolecular enol trapping of an allyl cation in acidic polar media. [D] . DeSelms, Robert Herschel. 2002

机译：1.研究针对通过高度官能化中间体的碘化sa（II）闭环合成20B-氨基苯甲酰吗啉酮类似物。 2.通过新型串联的羟醛-knoevenagel缩合合成5-氧代-环戊-1-烯羧酸甲酯。 3.通过在酸性极性介质中烯丙基阳离子的分子内烯醇捕获而形成新的碳环。
6. Asymmetric Synthesis of Tetrahydropyridines via anOrganocatalytic One-Pot Multicomponent Michael/Aza-Henry/CyclizationTriple Domino Reaction [O] . Marcus Blümel, Pankaj Chauhan, Robert Hahn, -1

机译：通过不对称合成四氢吡啶有机催化一锅多组分Michael / Aza-Henry /环化三重多米诺骨牌反应
7. Correction: One-pot synthesis of functionalized isoxazole–thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions [O] . Sakkani Nagaraju, Neeli Satyanarayana, Banoth Paplal, 2015

机译：校正：通过Knoevenagel缩合和Domino Sulfa-1,6-迈克尔/分子内乙烯基致反应的单壶合成官能化异恶唑 - 硫醇杂交物

One-pot synthesis of functionalized isoxazole- thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions

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